Glomerular injury and proteinuria in diabetes (types 1 and 2) and IgA nephropathy is related to the degree of podocyte depletion in humans. For determining the causal relationship between podocyte depletion and glomerulosclerosis, a transgenic rat strain in which the human diphtheria toxin receptor is specifically expressed in podocytes was developed. The rodent homologue does not act as a diph...

The genetic background plays an important role in the development of progressive glomerulosclerosis. However, no marker is available for the reliable prediction of genetic susceptibility to glomerulosclerosis. Because matrix metalloproteinase-9 (MMP-9) levels are decreased in models of glomerulosclerosis and MMP-9 promoter polymorphism has been observed among patients with diabetic nephropathy,...

Background : Diabetic nephropathy is the most common cause of end-stage renal disease and it has various pathologic features. We investigated the clinicopathologic differences between the histologic classes of diabetic nephropathy. Methods : A total of 46 patients with diabetic nephropathy were evaluated. Morphologically, the renal lesions were divided into three categories: class 1, diffuse or...

Progressive renal failure is accompanied by uncontrolled accumulation of extracellular matrix in glomeruli and tubulointerstitium, eventually resulting in glomerulosclerosis. Although glomerulosclerosis occurs secondary to various renal diseases, the fact that not all patients develop progressive glomerulosclerosis suggests that genetic factors may underlie the tendency to progress, or not to p...

I would like to show first the glomerulus of a 92-year-old man who did not have diabetes. It is perfectly normal. I want to emphasize that in the glomerulus there is not necessarily any ageing phenomenon per se. With the electron microscope there may be a slight increase in the thickness of the basement membrane of the glomerular capillary, but it is not visible by light microscopy. In the norm...

objective(s) oxidative stress plays an important role in diabetic nephropathy pathogenesis. rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy. material and methods forty male rats were uninephrectomized from the left flank.the rats were divided in four groups randomly; group one as control, group two diabetic untreatment, g...