BACKGROUND Overt diabetic nephropathy is accompanied by a progressive decline in glomerular filtration rate (GFR). In this study we have investigated if a reduction of GFR already during the transition from normo- to microalbuminuria is associated with glomerular structural changes. METHODS Seventeen adolescents (11 girls/6 boys) with 10.5 (3.3) (mean, SD) years of IDDM were studied. GFR was ...

Glomerular Filtration Rate (GFR) is routinely used to quantify kidney function; diagnose and follow dysfunctions. GFR can be measured or estimated using different estimation equations. equations are widely preferred in clinical practice. There multiple proposed endogenous filtration markers but there still a lack of consensus on their usage, especially the black population drug dosing. Our stud...

conclusions fasting in the month of ramadan in two consecutive years, and during the hottest months, in riyadh, saudi arabia, did not adversely affect kidney graft function. objectives to investigate the effect of repeated ramadan fasting during the hottest months of the year on renal graft functions. patients and methods this was a prospective cohort study comparing two groups of renal transpl...

Effects of an acute intravenous water load on glomerular and tubular function were studied in the anesthetized desert quail Lophortyx gambelii. Total-kidney glomerular filtration rate (GFR) and single-nephron glomerular filtration rates (SNGFR) of reptilian-type and mammalian-type nephrons increased by more than 50% compared with the GFR and SNGFRs measured during a control mannitol diuresis. D...

conclusions although our patient had ckd stage 4, but his condition has not deteriorated and remained constant and stable for several years only by control of blood pressure and usual treatment which prescribed for patients at this stage case presentation a 78-year-old man presented with stage 4 ckd for 7 years; the glomerular filtration rate (gfr) and creatinine levels remained constant despit...

Background: Glomerular filtration rate (GFR) estimation in older adults using a creatinine clearance/24-hour (CrCl) or an equation based on serum creatinine, are often considered equivalent by clinicians.

Glomerular filtration rate (GFR) is usually accepted as the best overall index of kidney function in health and disease. Normal GFR varies according to age, sex, and body size. In young adults it is approximately 120-130ml/ min/1.73 m2 and declines with age1. A decrease in GFR precedes the onset of clinical kidney failure; therefore, a persistently reduced GFR is a specific indication of chroni...

chronic kidney disease (ckd) is an increasing cause of morbidity and mortality worldwide. prospective data on risk factors for ckd are few. hypertension is one of the risk factors for ckd. in the past serum creatinine concentration was used as marker of kidney function but it proffers a late reflection of reduced glomerular filtration rate(gfr), which limits its ability to detect impaired kidne...

OBJECTIVE To compare performance of combined creatinine and cystatin C-based equation with equations based on either cystatin C or creatinine alone, in early chronic kidney disease. DESIGN Diagnostic accuracy study. SETTING Tertiary-care hospital. PATIENTS One hundred children with chronic kidney disease who underwent 99mTc diethylenetriamine pentaacetic acid (DTPA) glomerular filtration ...

This article reviews available radionuclide-based techniques for glomerular filtration rate (GFR) measurement, focusing on clinical indications for GFR measurement, ideal GFR radiopharmaceutical tracer properties, and the 2 most common tracers in clinical use. Methods for full, 1-compartment, and single-sample renal clearance characterization are discussed. GFR normalization and the role of GFR...