OBJECTIVE Dietary flavonoids and their metabolites may have neuroprotective effects against age-associated neurodegenerative disorders such as Alzheimer's and related dementias (dementia). There is a lack of population studies, however, on correlations between flavonoid intake and dementia. The main objective of the present study was to analyse such a relationship at a large-scale population le...

Evaluation of protective efficacy of live attenuated Salmonella enterica serovar 1 Gallinarum vaccine strains against fowl typhoid in chickens 2 3 Paweł Łaniewski, Arindam Mitra, Kemal Karaca, Ayub Khan, Rajeev Prasad, 4 Roy Curtiss III, Kenneth Roland 5 6 The Biodesign Institute and School of Life Sciences, Arizona State University, 7 Tempe, AZ, USA 8 Global Biological Research and Development...

this study was conducted to evaluate how neuroimaging procedures (mri, spect) could be used in clinical setting for diagnosis of dementia.forty out of 94 patients suspected of having a diagnosis of dementia, referred to radiology department for consecutive neuroimaging procedures, were selected. patients’ medical records reviewed anda retrospective diagnosis was reached according to dsm-iv for ...

Intraindividual variability of reaction time (IIVRT), a proposed cognitive marker of neurobiological disturbance, increases in old age, and has been associated with dementia and mortality. The extent to which IIVRT is an independent predictor of mortality, however, is unclear. This study investigated the association of IIVRT and all-cause mortality while accounting for cognitive level, incident...

BACKGROUND Efficient neuropsychological tests are needed to measure cognitive impairment in moderate to severe dementia. OBJECTIVE To examine construct validity of the Severe Impairment Battery Short Version (SIB-S) in nursing home patients with moderate to severe dementia, and to examine potential floor effects for the SIB-S. METHODS Cross-sectional comparison of cognitive measures, dement...

Alzheimer's disease, which is defined pathologically by abundant amyloid plaques and neurofibrillary tangles concurrent with synaptic and neuronal loss, is the most common underlying cause of dementia in the elderly. Among the oldest-old, those aged 90 and older, other ageing-related brain pathologies are prevalent in addition to Alzheimer's disease, including cerebrovascular disease and hippoc...

OBJECTIVES To evaluate a simple three step procedure to identify people in the general population who are in the preclinical phase of Alzheimer's disease and dementia. DESIGN Three year population based cohort study. SETTING Kungsholmen cohort, Stockholm, Sweden. PARTICIPANTS 1435 people aged 75-95 years without dementia. ASSESSMENTS Single question asking about memory complaints, asses...

BACKGROUND Quality of residential care for people with severe dementia is in urgent need of improvement. One reason for this may be the assumption that people with severe dementia are unaware of what is happening to them. However, there is converging evidence to suggest that global assumptions of unawareness are inappropriate. This trial platform study aims to assist care staff in perceiving an...

BACKGROUND In patients with very severe dementia self-rating of quality of life usually is not possible and appropriate instruments for proxy-ratings are not available. The aim of this project is to develop an instrument of clinical proxy-ratings for this population. METHODS Using electronic instruments, physicians and nurses recorded patient behaviour and changes of behaviour over a period o...

A meta-analysis has been performed including nineteen double blind, placebo controlled studies with piracetam in patients suffering from dementia or cognitive impairment in the elderly. These studies had as common outcome measure a clinical global impression of change, a measure of clinically meaningful improvement. The meta-analysis of this global outcome followed the methodology set forward b...