We quantified the number of glial fibrillary acidic protein immunoreactive (GFAP-IR) astrocytes in the CA1 and CA3 areas of the adult rat hippocampus. The dorsal and ventral regions of the hippocampus were taken into account to estimate the GFAP-IR cells using unbiased stereological techniques. Males had a higher number of GFAP-IR astrocytes in the CA3 area, whereas females had more in the CA1 ...

BACKGROUND Astrocytes and metabotropic glutamate receptors play important roles in nociceptive processing. However, their roles in bone cancer pain were not well understood. This study sought to investigate whether selective mGluR3 and mGluR5 agonist or antagonist develop antinociceptive effects on bone cancer pain by inhibition of spinal astrocyte activation. METHODS C3H/HeNCrlVr mice were i...

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein expressed predominantly in astrocytes. The study of its expression in the astrocyte lineage during development and in reactive astrocytes has revealed an intricate relationship with the expression of vimentin, another intermediate filament protein widely expressed in embryonic development. these findings suggested that v...

Clinical and experimental studies indicate a role for GH in mechanisms related to anhedonia/hedonia, psychic energy, and reward. Recently we showed that transgenic mice with general overexpression of bovine GH display increased spontaneous locomotor activity. In the present study, we investigated whether this behavioral change is owing to a direct action of GH in the central nervous system or t...

This study investigated the potential role of sirtuin 1 in Müller glial cells in choroidal neovascularization. In the in vitro study, primary Müller glial cells were cultured and treated with resveratrol, a sirtuin 1 activator. Glial fibrillary acidic protein expression and angiogenesis-related gene expression were examined using quantitative polymerase chain reaction and phagocytosis, as a mar...

Background: In this study, we examined a new two step induction protocol for improving the differentiation of human umbilical cord blood-derived mesenchymal stem cells into neural progenitor cells. Materials and Methods: Human umbilical cord blood-derived mesenchymal stem cells were first cultured in Dulbecco’s modified eagle medium supplemented with 10% fetal bovine serum in a humidified incu...

1995;133:61–5. 11. Rosengren LE, Ahlsen G, Belfrage M, Gillberg C, Haglid KG, Hamberger A. A sensitive ELISA for glial fibrillary acidic protein: application in CSF of children. J Neurosci Methods 1992;44:113–9. 12. Ehlers S, Kyllerman M, Rosengren L. Glial fibrillary acidic protein in the cerebrospinal fluid of children investigated for encephalopathy. Neuropediatrics 1994;25:134–9. 13. Doteva...

background: in recent years, adipose tissue, due to the stem cells contained within, has found a new special place in laboratory and clinical applications. these adipose‑derived stem cells (adscs) have the same characteristics of bone marrow mesenchymal stem cells (bmscs). although bone marrow (bm) is not easily accessible and its procurements may be painful, most patients possess excess fat wh...