Ghrelin was recently isolated from the rat stomach as an endogenous ligand for the GH secretagogue receptor. Although it is well known that a large amount of ghrelin is produced in the gastrointestinal tract, developmental changes in ghrelin mRNA expression and differentiation of ghrelin-immunopositive (ghrelin-ip) and mRNA-expressing (ghrelin-ex) cells in the stomach have not been elucidated. ...

A composite glandular/exocrine-endocrine carcinoma of the gastrointestinal tract is characterized by the co-existence of two adjacent, but histologically-distinct tumors in an organ. Composite glandular/exocrine-endocrine carcinomas are a special type of tumor comprised of common adenocarcinomas and neuroendocrine components that account for at least one-third of the entire tumor area. Composit...

Mouse models with conditional activation of K-ras (K-ras(G12D)) are used widely to investigate the role of oncogenic K-ras in a tissue-specific manner. However, the effect of ubiquitous activation of K-ras in adult mice has not been well studied. Herein, we report that systemic activation of K-ras in mice leads to rapid changes in gastric cellular homeostasis. Conditional activation of K-ras re...

The gastrointestinal morphology was investigated in three mammalian insectivorous species, namely Acomys spinosissimus, Crocidura cyanea, and Amblysomus hottentotus. The aim of the study was to provide a comprehensive morphological comparison between the different species and to explore whether anatomical gastrointestinal adaptations are associated with the insectivorous diet of these species. ...

T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2DM and T1DM were induced in Psammomys obesus (PO) by high-energy (HE) diet and ...

Histological development of digestive tract of the Caspian salmon, Salmo trutta caspius, from hatching to 6 month post-hatching was studied using light microscope. The digestive tract of newly hatched larvae was a simple, undifferentiated tube which continued from mouth to anus. In 10 days post hatching larvae, the alimentary canal became more differentiated and secretion was started activity, ...

Mouse fetal intestinal progenitors lining the epithelium prior to villogenesis grow as spheroids when cultured ex vivo and express the transmembrane glycoprotein Trop2 as a marker. Here, we report the characterization of Trop2-expressing cells from fetal pre-glandular stomach, growing as immortal undifferentiated spheroids, and their relationship with gastric development and regeneration. Trop2...

SCANNING AND TRANSLUCENT ELECTRON MICROSCOPIC OBSERVATION OF SQUAMO-GLANDULAR JUNCTION IN THE ESOPHAGO-GASTRIC JUNCTION Yoshio OKADA*t, Yasusada AKAMINE, Kazuo KARASAWA and Kinya SAWADA * 2nd Surgical Department (if Aichi Cancer Center Hospital t Department rif Thoracic Surgery, Chest Disease Research Institute, Kyoto University Squamo-glandular junction in the esophago-gastric junction was obs...

OBJECTIVES To investigate if oral omeprazole application induces cancers of fore and glandular stomach in mice. METHODS A total of 66 eligible male mice were randomly divided into 6 groups, which were treated with control reagent, low (6 mg/kg) and high dose omeprazole (30 mg/kg), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG, 100 mg/L water), and MNNG plus low and high dose omeprazole, respecti...

Histological development of digestive tract of the Caspian salmon, Salmo trutta caspius, from hatching to 6 month post-hatching was studied using light microscope. The digestive tract of newly hatched larvae was a simple, undifferentiated tube which continued from mouth to anus. In 10 days post hatching larvae, the alimentary canal became more differentiated and secretion was started activity, ...