CONTEXT Novel antimalarial agents are in demand due to the emergence of multidrug resistant strains. Ginseng, a medicinal plant with antiparasitic activity, contains components that can be used to treat the tropical disease malaria. OBJECTIVE Ginsenosides and polysaccharides are active components of ginseng. This study aimed to elucidate the ability of these compounds to inhibit the replicati...

BACKGROUND The effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model. METHODS Catheters were placed into the intrathecal space of male Sprague-Dawley rats. Postoperative pain was evoked by an incision to the plantar surface of a hind paw. Withdrawal thresholds was used as a nociceptive ...

BACKGROUND Rare ginsenosides in Panax quinquefolius L. have strong bioactivities. The fact that it is hard to obtain large amounts of rare ginsenosides seriously restricts further research on these compounds. An easy, fast, and efficient method to obtain different kinds of rare ginsenosides simultaneously and to quantify each one precisely is urgently needed. METHODS Microwave-assisted extrac...

BACKGROUND Ginsenosides are the major components responsible for the biochemical and pharmacological actions of ginseng, and have been shown to have various biological activities. In this study, we investigated the antiviral activities of seven ginsenosides [protopanaxatriol (PT) type: Re, Rf, and Rg2; protopanaxadiol (PD) type: Rb1, Rb2, Rc, and Rd)] against coxsackievirus B3 (CVB3), enterovir...

Even though the degradation of ginsenosides has been thoroughly studied in animals and in vitro using acids, enzymes, and intestinal bacteria, knowledge concerning the systemic availability of ginsenosides and their degradation products in humans is generally lacking. Therefore, the attention in this article is focused on the identification of ginsenosides and their hydrolysis products reaching...

The root of the ginseng plants has been used as herbal medicine in Asia for over two thousand years. It is purported to possess antioxidant, anticarcinogenic, anti-inflammatory, antihypertensive and anti-diabetic properties. The pharmacologically active compounds behind the claims of ginseng's efficacy are ginsenosides; their underlying mechanism of action, although not entirely elucidated, app...

BACKGROUND Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. METHODS Medium-pressure liquid chromatography and semipreparative high-performance liquid chromatography were used to isolate purified...

out direct bacterial or viral infection is irritable bowel syndrome (IBS), which is strongly associated with stress. The most common IBS symptoms are abnormal visceral discomfort, pain and diarrhea. Although the precise mechanism of IBS has not been fully elucidated, some symptoms of IBS are thought to involve the 5-hydroxytryptamine receptor3 (5HT3). Zacopride, a 5-HT3-receptor antagonist, has...

BACKGROUND Bone cancer pain has a disruptive effect on the cancer patient's quality of life. Although ginsenosides have been used as traditional medicine in Eastern Medicine, the effect on bone cancer pain has not been thoroughly studied. The aim of this study was to determine whether ginsenosides may alter the bone cancer pain at the spinal level. METHODS NCTC 2472 tumor cells (2.5 × 10(5)) ...

OBJECTIVE To compare the dissolution properties of Ginseng micropowder and common powder in vitro and investigate the effect of micronization on dissolution of Ginseng. METHODS Five ginsenosides including Rg1, Re, Rf, Rb1, and Rb2 were determined by high performance liquid chromatography, and the dissolution curves of Ginseng micropowder and common powder were drawn. RESULTS The dissolution...