Gestational trophoblastic neoplasia (GTN) includes the abnormal pregnancies complete (CHM) and partial hydatidiform mole (PHM) and the malignant gestational trophoblastic tumours (GTT) invasive mole (IM), choriocarcinoma, placental site trophoblastic tumour (PSTT) and epithelioid trophoblastic tumour (ETT). While many genetic studies have been performed in both CHM and PHM, similar studies of t...

•We present two cases of postmolar gestational trophoblastic neoplasia (GTN).•Both cases presented with lung metastases after hydatidiform mole.•Both cases showed spontaneous regression without treatment.•The mechanism behind this phenomenon remains unclear.•Patients with postmolar GTN and declining hCG values may not need chemotherapy.

Introduction: Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the e...

background : gestational trophoblastic neoplasia (gtn) refers to malignant lesions that arise from abnormal proliferation of placental trophoblast. even in its metastatic forms gtn is curable with a cure rate of 90-100 %. currently, methotrexate with or without folic acid, andactinomycin d is recommended for low risk gtn. the aim of this study is to compare the efficacy of methotrexate and acti...

The treatment of gestational trophoblastic neoplasia (GTN) represents one of the modern success stories in cancer medicine. Early diagnosis, effective treatments, monitoring of response with a series of serum human chorionic gonadotropin levels, and centralized care have all contributed to this success. Nevertheless, some patients relapse after initial chemotherapy. This review discusses the ro...

OBJECTIVES The objectives of this study were to analyze deaths after gestational trophoblastic neoplasia and to determine the factors of treatment failure. METHODS This is a retrospective study in Aristide Le Dantec teaching Hospital in Dakar, Senegal, between 1 January 2006 and 31 December 2014. We took into account socio-epidemiological characteristics of patients, initial diagnosis, time b...

Gestational trophoblastic neoplasia (GTN) is highly chemosensitive and has a high cure rate. Since the introduction of chemotherapy, reliable measurement of human chorionic gonadotropin (hCG) levels, and individualised risk-based therapy into the management of GTN, almost all low-risk and more than 80 % of high-risk GTN cases are curable. However, approximately 25 % of high-risk GTN developed r...

Gestational trophoblastic neoplasia (GTN) is a spectrum of diseases including partial and complete hydatidiform moles, placental site trophoblastic tumor, and choriocarcinoma. One of the most important considerations is recognition of the possibility of GTN after molar pregnancy or even normal pregnancy. It is common practice to use chest x-ray for the detection of pulmonary metastasis. Compute...

Gestational trophoblastic neoplasia (GTN) includes the abnormal pregnancies complete (CHM) and partial hydatidiform mole (PHM) and the malignant gestational trophoblastic tumours (GTT) invasive mole (IM), choriocarcinoma, placental site trophoblastic tumour (PSTT) and epithelioid trophoblastic tumour (ETT). While many genetic studies have been performed in both CHM and PHM, similar studies of t...

Introduction: Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the e...