Germinal matrix–intraventricular hemorrhage (GMH-IVH) is a common and characteristic form of intracranial hemorrhage occurring in the premature infant. The hemorrhage originates in small blood vessels in the subependymal germinal matrix (also termed the ganglionic eminence) and may disrupt the ependymal lining and extend into the lateral ventricle. Severe IVH consists of large amounts of intrav...

BACKGROUND AND PURPOSE Although indomethacin has been demonstrated to prevent germinal matrix and intraventricular hemorrhage in clinical and animal studies, the mechanism of action of this agent to prevent hemorrhage remains unclear. Previous studies have demonstrated both that the microvessels in the germinal matrix of newborn beagle pups undergo basement membrane maturation during the first ...

intraventricularhemorrhage (ivh) is one of thecommon morbidities among preterm neonates. in thepresentstudy, we set out to evaluate the efficacy of two prophylactic modalities (ibuprofen and indomethacin prophylaxis) for prevention of ivh in our local setting. a prospective study was carried out in akbar-abadi hospital, tehran-iran (2013-2014). ninety-six preterm neonates who cared in closed in...

Objective: Preterm infants are prone to intraventricular hemorrhage. They may suffer from significant morbidity and mortality particularly in those with high-grade hemorrhage. Our objective was to determine the incidence of intraventricular hemorrhage in premature infants transported to a tertiary center compared with those delivered at the level III facility.  Methods: We evaluated all prematu...

Introduction Intracranial hemorrhage is common in neonates, especially in preterm neonates. Different types of hemorrhage have been diagnosed in neonates including germinal matrix hemorrhage, intraventricular hemorrhage, intraparenchymal hemorrhage, venous lesions or extra-axial hemorrhage with various etiologies such as asphyxia, premature delivery and assisted vaginal delivery. Susceptibility...

objective: preterm infants are prone to intraventricular hemorrhage. they may suffer from significant morbidity and mortality particularly in those with high-grade hemorrhage. our objective was to determine the incidence of intraventricular hemorrhage in premature infants transported to a tertiary center compared with those delivered at the level iii facility.  methods: we evaluated all prematu...

In 34 consecutive infants admitted to the neonatal intensive care unit with birth weight of less than 1,500 g, 80 cranial real-time sonograms were obtained to determine the incidence of choroid plexus hemorrhage. Choroid plexus hemorrhage was diagnosed only in the absence of germinal matrix hemorrhage. Diagnostic criteria included choroid plexus nodularity, enlargement (greater than 12 mm in an...

The etiology of intraventricular hemorrhage (IVH) in extremely low birth weight preterm infants is multifactorial with circulatory instability and hemostasis being preeminent. This study sought to determine if the germinal matrix layer remained intact when platelets were above 200 × 10(9)/L, a near normal level, and fell below that when IVH occurred. This was a retrospective study of platelets ...