BACKGROUND AND AIM Granulin-epithelin precursor (GEP) has previously been reported to control cancer growth, invasion, chemo-resistance, and served as novel therapeutic target for cancer treatment. However, the nature and characteristics of GEP interacting partner remain unclear. The present study aims to identify and characterize the novel predominant interacting partner of GEP using co-immuno...

BACKGROUND Lung cancer is an important and common cancer that constitutes a major public health problem, but early detection of small cell lung cancer can significantly improve the survival rate of cancer patients. A number of serum biomarkers have been used in the diagnosis of lung cancers; however, they exhibit low sensitivity and specificity. METHODS We used biochemical methods to measure ...

PURPOSE Granulin-epithelin precursor (GEP) is a novel growth factor. Our earlier cDNA microarray study indicated that GEP was overexpressed in hepatocellular carcinoma (HCC). The aim of this study was to investigate the clinical significance of GEP expression and its potential as a therapeutic target in HCC. EXPERIMENTAL DESIGN A total of 110 pairs of HCCs and adjacent nontumor liver tissues,...

PURPOSE This study evaluates the prognostic performance of a 15 gene expression profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic subgroups: class 1 (low metastatic risk) and class 2 (high metastatic risk). DESIGN Prospective, multicenter study. PARTICIPANTS A total of 459 patients with posterior uveal melanoma were enrolled from 12 independent centers. TE...

Is the risk of metastasis equivalent between a class 2 tumor (GEP) and monosomy 3 tumor as determined by MLPA? The concordance between these tests in patients with uveal melanoma undergoing a prognostic fine-needle aspiration biopsy (FNAB) has not been studied until recently. In a retrospective study, GEP and FISH (44 patients) or GEP and MLPA (49 patients – 6 technical failures GEP [3] and MLP...

The PnET-Day model was independently parameterized to compare with estimated eddy covariance gross ecosystem production (GEP; gC m 2 day ) in a mature mixed hardwood and a mature red pine (Pinus resinosa) forest in Northern Wisconsin during the growing season of 2002 and 2003. The mature hardwood forest was dominated by Populus tremuloides, Populus grandidentata, Betula papyrifera, Quercus rubr...

BACKGROUND A single non-invasive gene expression profiling (GEP) test (AlloMap®) is often used to discriminate if a heart transplant recipient is at a low risk of acute cellular rejection at time of testing. In a randomized trial, use of the test (a GEP score from 0-40) has been shown to be non-inferior to a routine endomyocardial biopsy for surveillance after heart transplantation in selected ...

PURPOSE Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy and tumor growth. As conservative treatment options for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) are disappointing, aurora kinases may be an interesting target for novel therapeutic strategies. EXPERIMENTAL DESIGN Human GEP-NETs were tested for a...

Positive pathogens prediction is the basis of pathogenic spectrum analysis, which is a meaningful work in public health. Gene Expression Programming (GEP) can develop the model without predetermined assumptions, so applying GEP to positive pathogens prediction is desirable. However, traditional time-adjacent sliding window may not be suitable for GEP evolving accurate prediction model. The main...

Impairment of natural killer (NK) cell activity is an important mechanism of tumor immunoevasion. We have previously shown that expression of granulin-epithelin precursor (GEP) in hepatocellular carcinoma (HCC) cells rendered the cells resistant to NK cell immunosurveillance. Here, we examined whether targeting GEP could rescue NK activity in HCC patients. The current study demonstrated that qu...