different research groups have extensively studied the associations of cytokine gene polymorphisms in different diseases. the role of cytokines gene polymorphisms in multiple sclerosis (ms), as a chronic immune-mediated neurodegenerative disease, has been previously reported in the various populations. for determining pro-inflammatory cytokine gene polymorphisms, 100 relapsing remitting multipl...

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The chromosome 19q 13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS. In a cross-sectional study, to show the APOE genotype and allele frequency in the MS population of Iran in comp...

Background: CCL22/MDC is a CC chemokine with a critical role in regulation of the immune balance in physiological condition. CCL22/CCR-4 ligation has been documented to participate in the migration of regulatory T (Treg) cells and Th2 lymphocytes to the site of breast tumors; circumstances that are known to be associated with poor prognosis. Objective: To investigate the association of a single...

objective(s): apolipoprotein e genotype (apoe) polymorphism affects lipid levels and coronary artery disease (cad) risk. the aim of this study was to study the association of the apolipoprotein e genotypes with coronary artery disease in the iranian population.   materials and methods: the apolipoprotein e genotype in dna samples extracted from 66 cad+ patients and 61 control subjects by restri...

BACKGROUND Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. METHODS Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves' disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls. RESULTS GD sho...

Objectives This study aimed to assess PD-1gene polymorphism in salivary gland tumors in patients referred to Khalili Hospital in Shiraz. Methods This case-control study evaluated 48 patients with salivary gland tumors and 100 age- and sex-matched healthy controls. First, 5cc blood samples were obtained from patients and transferred to vials containing anti-coagulated EDTA. DNA was extracted, a...

aim : the purpose of this study was to compare the distribution of interleukin (il)-28b genotypes between iranian healthy individuals and patients with chronic hepatitis c based on the genotype. background : polymorphisms in the region of il-28b gene have been identified as the strongest genetic pretreatment predictor of sustained virological response (svr) in hepatitis c infection. patients an...

The genetic polymorphism of some genes related to meat production in three Egyptian sheep breeds (Barki, Rahmani and Osseimi) was studied. The candidate genes were: Calpastatin, Myostatin, Diacylglycerol-acyltransferase1, Insulin-like growth factor binding protein-3 and Booroola fecundity gene. The technique applied was the restriction fragment length polymorphism for the polymerase chain react...