M.J. Korstanje, Department of Dermatology, Academic Hospital Maastricht, PO Box 1918, NL–6201 BX Maastricht (The Netherlands) The effectiveness of ciclosporin (CsA) in severe plaque psoriasis is established [1. 2]. However. CsA may not be randomly used in clinical practice because of its side effects, which include hepatotoxicity. acute and chronic nephrotoxicity, hirsutism. hypertension and to...