objective(s):to the best of our knowledge, this is the first report on the contributions of gst genetic variants to the risk of diabetic retinopathy in an iranian population. therefore, the objective of this study was to determine whether sequence variation in glutathione s-transferase gene (gstm1 and gstt1) is associated with development of diabetic retinopathy in type 2 diabetes mellitus (t2d...

conclusions polymorphism in the hemochromatosis gene may confer some degree of risk for hcv infection, and individuals carrying the h and c alleles may be susceptible to this disease; however, a larger sample of hcv patients and healthy individuals may be necessary to further illustrate the role of these polymorphisms in hcv. patients and methods hfe gene polymorphisms were examined in a total ...

Background: Thousands of genes are involved in spermatogenesis. Alterations in any of these genes could lead to male infertility. Moloney leukemia virus 10-Like 1 (Mov10l1) gene is one of the genes that are expressed specifically in germ cells. Genetic disruption of this gene in mouse stops spermatogenesis during Meiosis I and causes azoospermia. Materials and Methods: In this study, the geneti...

atopic dermatitis (ad) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of t-helper 2 cells. the aim if this study was to determine whether cytokine gene polymorphisms might influence the development of ad. single nucleotide polymorphisms in the genes for i-l1alpha, il-1beta, il-1r, il-2, il-4, il-6, il-10, il-12, tgf beta, tnf and ifng...

the underlying mechanisms leading to the development of human t-cell lymphotropic virus type i (htlv-i) associated myelopathy/tropical spastic paraparesis (ham/tsp) in htlv-i infected individuals are not fully understood. host genetic factors appear to be involved as risk factors for developing ham/tsp. we investigated the possible contribution of interleukin-10 (il-10) as a risk factor to ham/...

the environmental procarcinogen which are responcible for carcinogenesis, to form the proximate carcinogen, they require metabolic activation by drug metabolizing enzymes. the cyp3a subfamily enzymes play an important role in elimination of drugs. the substrates for cyp3a4 enzyme include drugs, and endogenous substances. therefore, allelic changes in the coding regions of cyp3a4, increases the ...

Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...

background: polycystic ovary syndrome (pcos) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology. objective: we examined the possible association of adiponectin and insulin receptor gene polymorphisms with pcos. materials and methods: a total of 186 women with pcos using...

introduction genetic background has known to be associated with the outcome of human t cell lymphotropic virus (htlv) type i infection. in the present study we investigate the association between gm-csf gene polymorphisms with the outcome of htlv-i infection. materials and methods we analyzed 3 single-nucleotide polymorphisms in the promter region of granulocyte macrophage colony stimulating fa...

conclusions the at1r a1166c polymorphism appeared not to be associated with the presence of acs in the population studied. background there are very limited data for iranian populations on the predisposing genetic factors for acute coronary syndrome (acs). results there was no statistical difference in the genotype frequency of patients and healthy subjects with regard to age and gender (p > 0....