background: gp41 of hiv (human immunodeficiency virus) is a protein that mediates fusion between viral and cellular membranes. the agent, t-20, which has been approved for hiv inhibition, can restrain gp41 function in the fusion process; nevertheless, it has disadvantages like instability, high cost of production and injection form to be delivered twice a day. methods: several molecules like nb...

Mutation in the BRAF V600E gene metastatic colorectal cancer (CRC) occurs 510% of cases and is a significant problem due to aggressive course extremely unfavorable prognosis. In recent years, new treatment options for mutated CRC have been emerging, example, combinations inhibitors, anti-EGFR antibodies with optional addition MEK inhibitors. The possibility local methods also being discussed. O...

The p21 belongs to the CIP/KIP family of CDK inhibitors involved in cell cycle arrest at specific stages of the cell cycle progression. DNA methylation is the best studied epigenetic mark that have been evidently associated to chromatin condensation, and repression of gene transcription. The CpG island hypermethylation in promoter region of certain genes occurs in cancer cells and affects tumor...

Background Recent studies suggested Contactin-associated protein-like 2 (CNTNAP2) as a novel risk gene for Alzheimer’s disease (AD). Reduced expression levels of CNTNAP2 were found in the brains AD patients. However, mechanisms underlying protein degradation remain elusive. Method HEK and N2a cells transfected with human plasmid treated cycloheximide, lysosome inhibitors, proteasome inhibitors....

Backgraound . High-grade serous ovarian carcinoma (HGSOC) is the most common type of cancer. The prevalence BRCA1/2 germline mutations highest in HGSOC. patients with BRCA gene are more likely to respond platinum-based chemotherapy. Clinical trials demonstrate effectiveness PARP inhibitors treatment -associated Re-administration after response chemotherapy demonstrates an increase progression-f...

the p21 belongs to the cip/kip family of cdk inhibitors involved in cell cycle arrest at specific stages of the cell cycle progression. dna methylation is the best studied epigenetic mark that have been evidently associated to chromatin condensation, and repression of gene transcription. the cpg island hypermethylation in promoter region of certain genes occurs in cancer cells and affects tumor...

The gene family of protein phosphatases is a rich but under-exploited source therapeutically validated drug targets modulating signal transduction pathways. Unlike the kinase family, research and development activities have not yet yielded any approved small-molecule drugs against phosphatase. Approximately 20 years ago, phosphatase was classified as undruggable intractable. This primarily due ...