We present a complete FIR spectral energy distribution of a normal spiral disk. A full grating scan, from 43–189 μm, centered on the nucleus of NGC 4414 was made with the ISO Long Wavelength Spectrometer (LWS). The midIR to millimeter continuum of NGC 4414 can be modeled with thermal dust emission from a warm component at 69 K and a cool component at 24.5 K. At a distance of 9.6 Mpc, the LWS be...

Gelucire 50/13 (G50/13) was assessed to develop controlled release formulation of salbutamol sulphate (SBL) a highly water soluble drug by semisolid matrix filling capsule technique. Drug release profiles of SBL release by using G50/13 and its blends with other hydrophilic or hydrophobic materials were investigated. Lipid matrix formulations prepared with increasing amount of polymer showed a s...

Gelucire is the family of vehicle derived from mixtures of mono-, diand tri-glycerides with PEG esters of fatty acids. They have a wide variety of application in pharmaceutical formulations. These are used in the preparation of fast release and sustained release formulations. In order to increase the bioavailability of drugs, the residence time of the orally administered dosage form in the uppe...

We present three-frequency VLA observations of the flocculent spiral galaxy NGC 4414 made in order to study the magnetic field structure in absence of strong density wave flows. NGC 4414 shows a regular spiral pattern of observed polarization B-vectors with a radial component comparable in strength to the azimuthal one. The average pitch angle of the magnetic field is about 20 • , similar to ga...

A solid dispersion of Meloxicam (MX), a poorly soluble, non steroidal anti-inflammatory drug, and Gelucire 50/13 was prepared by spray drying. Spherical microparticles were yielded with smooth surfaces as observed by scanning electron microscopy. According to differential scanning calorimetry and powder X-ray diffractometry analysis, MX was transformed from the crystalline state to the amorphou...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

The challenge in developing oral drug delivery systems of poorly soluble basic drugs is primarily due to their pH dependent solubility. Cinnarizine (CNZ), a model for a poorly soluble basic drug, has pH dependent solubility; where it dissolves readily at low pH in the stomach and exhibits a very low solubility at pH values greater than 4. It is also characterized by a short half life of 3-6h, w...

The aim of this investigation was to improve the dissolution properties of the water-insoluble drug ezetimibe (EZE) and potentially improve bioavailability. A combination of melt and adsorption techniques was employed for the preparation of solid dispersions. PEG 4000, PEG 6000, and Gelucire 44/14 were used as hydrophilic carriers, and lactose monohydrate was used as an adsorbent. Phase solubil...

Ouron-goingobservations of the interstellarmedium of NGC 4414 have resulted in CO(1–0) and CO(2–1) detections to very close to the optical edge of the disk. The 13CO lines and thermal dust continuum emission have been detected almost as far out. The variation in the beam-independent CO(2−1 1−0 ) line intensity ratio is interpreted in terms of a variation in the CO excitation temperature. Combin...