In our previous work, the effect of use of a water soluble CDI/NHS system as nontoxic cross-linking agent on fabrication of gelatin nanoparticles was investigated. In this research, the effect of variation in some synthetic parameters of gelatin nanoparticles cross-linked by CDI/NHS system such as type of gelatin and formulation of cross- linking agent on their size and distribution was examine...

the present work focuses on preparation and characterization of erythromycin loaded gelatin nanoparticles through nanoprecipitation method. the procedure consists of the increase of the aqueous gelatin solution to the non-solvent phase containing lutherol f127. three different measures of cross-linker and polymer concentration were also examined, and the optimum concentration was found. the mor...

Gelatin is a natural biocompatible, nontoxic, edible and an inexpensive molecule. These properties result in its wide applications and recently it has been used for the delivery of the gene therapeutic entities such as plasmid DNA and paclitaxel drug based delivery for the various types of Cancer cells including Bladder cancer cells and prostate cancer cells. Generally, gelatin nanoparticles ca...

In this research, gelatin nanoparticles were synthesized via inverse miniemulsion method by employing a mixture of a water soluble carbodiimide (CDI) and N-hydroxysuccinimide (NHS) as a non-toxic cross-linking system. The gelatin nanoparticles were characterized for their size and size distribution, morphology and stability and were compared with those of nanoparticles cross-linked by glutarald...

RNA oligonucleotides have emerged as a new class of biologicals that can silence gene expression but also stimulate immune responses through specific pattern-recognition receptors. The development of effective delivery systems remains a major challenge for the therapeutic application of the RNA oligonucleotides. In this study, we have established a novel biodegradable carrier system that is hig...

Palladium nanoparticles were deposited and reduced by gelatin as a safe edible, naturally occurring and cheap support. No extra reducing agents were used for the generation of Pd(0) nanoparticles from the Pd(II) salt. The nanoparticles of Pd supported on gelatin were characterized by SEM, TEM and AFM images, UV-Vis and XRD spectra and the amount of palladium entrapped in the gelatin was measure...

The present work focuses on preparation and characterization of erythromycin loaded gelatin nanoparticles through nanoprecipitation method. The procedure consists of the addition of the aqueous gelatin solution to the non-solvent phase containing Lutherol F127. Three different measures of cross-linker and polymer concentration were also examined, and the optimum concentration was found. The mor...

The objective of this study was formulation and evaluation of mucoadhesive nanoparticles of acyclovir. Nanoparticles were prepared by one step desolvation method by using gelatin as a mucoadhesive polymer. The effects of amount of gelatin and Pluronic F-68 on particle size, polydispersity index, entrapment efficiency, loading efficiency, mucoadhesive strength were studied. Nanoparticulate formu...

BACKGROUND Gene transfer using a nanoparticle vector is a promising new approach for the safe delivery of therapeutic genes in human disease. The Tat peptide-decorated gelatin-siloxane (Tat-GS) nanoparticle has been demonstrated to be biocompatible as a vector, and to have enhanced gene transfection efficiency compared with the commercial reagent. This study investigated whether intracisternal ...

Asymmetrical flow field-flow fractionation (AF4) offers unique separation properties for macromolecules, colloids, particles, and even cells from human or animal origin. At the same time the characterization of non viral colloidal drug delivery systems by means of AF4 is barely described in literature. Here, three different analytical tasks investigating gelatin nanoparticles as drug delivery s...