Gong, Ming Cui, Isabelle Gorenne, Paul Read, Taiping Jia, Robert K. Nakamoto, Avril V. Somlyo, and Andrew P. Somlyo. Regulation by GDI of RhoA/Rho-kinase-induced Ca21 sensitization of smooth muscle myosin II. Am J Physiol Cell Physiol 281: C257–C269, 2001.—We characterized the role of guanine nucleotide dissociation inhibitor (GDI) in RhoA/Rho-kinase-mediated Ca21 sensitization of smooth muscle...

In low-voltage and low-power applications, optimization of several devices for speed and power is a significant issue. These issues can be overcome by incorporating Modified Gate Diffusion Input (Mod-GDI) technique. This technique has been adopted from Gate Diffusion Input (GDI). The Mod-GDI technique allows reducing power consumption, delay and area of digital circuits, while maintaining low c...

This article describes a new multivariate measure of overall gait pathology called the Gait Deviation Index (GDI). The first step in developing the GDI was to use kinematic data from a large number of walking strides to derive a set of mutually independent joint rotation patterns that efficiently describe gait. These patterns are called gait features. Linear combinations of the first 15 gait fe...

Growing evidences indicate that Ly-GDI, an inhibitory protein of Rho GTPases, plays an essential role in regulating actin cytoskeletal alteration which is indispensible for the process such as phagocytosis. However, the role of Ly-GDI in inflammation remains largely unknown. In the current study, we found that Ly-GDI expression was significantly decreased in the IgG immune complex-injured lungs...

Insulin stimulates GLUT4 (glucose transporter 4) translocation in adipocytes and muscles. An emerging picture is that Rab10 could bridge the gap between the insulin signalling cascade and GLUT4 translocation in adipocytes. In the present study, two potential effectors of Rab10, GDI (guanine-nucleotide-dissociation inhibitor)-1 and GDI-2, are characterized in respect to their roles in insulin-st...

The small GTPase Rab1 is required for vesicular traffic from the ER to the cis-Golgi compartment, and for transport between the cis and medial compartments of the Golgi stack. In the present study, we examine the role of guanine nucleotide dissociation inhibitor (GDI) in regulating the function of Rab1 in the transport of vesicular stomatitis virus glycoprotein (VSV-G) in vitro. Incubation in t...

This article introduces a new index, the GDI-Kinetic; a direct analog of the GDI based on joint kinetics rather than kinematics. The method consists of: (1) identifying "features" of the raw gait kinetic data using singular value decomposition, (2) identifying a subset of features that account for a large percentage of the information in the raw gait kinetic data, (3) expressing the raw data fr...

G TPases of the Rab family, which comprises more than 60 members in mammals, have emerged as key regulators of virtually all transport steps between intracellular compartments. By interacting with a diverse range of effector proteins, such as lipid kinases and phosphatases, molecular motors, tethering factors, and scaffolding proteins, they regulate the formation of transport carriers from dono...

OBJECTIVE To investigate face and construct validity of the Gait Deviation Index (GDI) in adults with spastic cerebral palsy. The International Classification of Functioning, Disability and Health (ICF) was used as a framework, defining gait and walking as the manner or style of walking ("body function"), and the execution of gait ("activity"), respectively. DESIGN A cross-sectional study. ...

The Rho GDP dissociation inhibitor (GDI) forms a complex with the GDP-bound form of the Rho family small G proteins and inhibits their activation. The GDP-bound form complexed with Rho GDI is not activated by the GDP/GTP exchange factor for the Rho family members, suggesting the presence of another factor necessary for this activation. We have reported that the Rho subfamily members regulate th...