The objective of present work was to formulate and evaluate Fluconazole (FLZ) microsponges using quasi emulsion solvent diffusion technique and microsponge gel by using carbopol. Microsponges containing FLZ were obtained successfully with different proportions of ethyl cellulose polymer (EC). The formulations were studied for particle size and physical characterization. The physical characteriz...

The aim of the present study was to design a novel topical skin-target drug-delivery system, the paeonol microsponge, and to investigate its drug-release patterns in dosage form, both in vitro and in vivo. Paeonol microsponges were prepared using the quasi-emulsion solvent-diffusion method. In vitro release studies were carried out using Franz diffusion cells, while in vivo studies were investi...

In the present work, paracetamol loaded eudragit based microsponges were prepared using quasi-emulsion solvent diffusion method. The compatibility of the drug with various formulation components was established. Process parameters were analyzed in order to optimize the formulation. Shape and surface morphology of the microsponges were examined using scanning electron microscopy. The formulation...

OBJECTIVE The rationale behind present research vocation was to develop and investigate a novel microsponge based gel as a topical carrier for the prolonged release and cutaneous drug deposition of fluconazole (FLZ); destined for facilitated fungal therapy. MATERIALS AND METHODS Microsponges were prepared using quasi-emulsion solvent diffusion method using Eudragit S-100. In the direction of ...

Background Brucea javanica oil (BJO), a traditional Chinese herbal medicine, has a variety of pharmacological activities and several BJO-related patent drugs have been widely used in China. Purpose The objective of this study was to evaluate the gastric therapeutic effects of self-made BJO and its pharmaceutical potential to formulate novel BJO gastroretentive floating bead by comparing with ...

One approach for delivery of narrow absorption window drugs is to formulate gastroretentive drug delivery systems. This study was undertaken to provide insight into in vivo performances of two gastroretentive systems (PXLNET and IPB matrices) in comparison to Madopar® HBS capsules. The pig model was used to assess gastric residence time and pharmacokinetic parameters using blood, cerebrospinal ...

The oral absorption and hence the bioavailability of carbamazepine (CBZ) is variable even after administration rapidly dissolving formulation. This problem was attributed to supersaturation CBZ transformation less soluble dihydrate (CBD). Accordingly, formulation sustained release products a promising approach overcome this problem. Microsponges are an emerging which can help in direction. aim ...

Microsponge containing ketotifen drug with three different proportions of ethyl cellulose and drug were obtained successfully using quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. These microsponges enriched gel formulation were prepared by using 2 and 3 % w/w of SCMC and studied for viscosity, pH, gel strength, spreadabi...

Objective: Purpose of the study to design and formulate Diclofenac sodium (DIC) microsponges. Methods: With varied polymer: drug ratio DIC loaded microsponges were prepared with Eudragit RS100 polymer by quasi solvent diffusion method. Microsponges evaluated for particle size, entrapment efficiency, content, in vitro release, Fourier Transform Infrared Spectroscopy (FTIR), Differential scanning...