BACKGROUND To report on the acute toxicity in children with medulloblastoma undergoing intensity-modulated radiation therapy (IMRT) with daily intrafractionally modulated junctions. METHODS Newly diagnosed patients, aged 3-21, with standard-risk (SR) or high-risk (HR) medulloblastoma were eligible. A dose of 23.4 or 36.0 Gy in daily fractions of 1.8 Gy was prescribed to the craniospinal axis,...

BACKGROUND To report the toxicity after intensity modulated radiotherapy (IMRT) for patients with localized prostate cancer, as a sole treatment or after radical prostatectomy. METHODS Between August 2001 and December 2003, 132 patients with prostate cancer were treated with IMRT and 125 were evaluable to acute and late toxicity analysis, after a minimum follow-up time of one year. Clinical a...

Acute iron toxicity is usually seen in children with accidental ingestion of iron-containing syrups. However, the literature on acute iron toxicity with suicidal intent in adults is scant. We report, the first instance of two adults with fatal ingestion of a single drug overdose with iron tablets from India. Two young adults developed severe gastro-intestinal bleeding and fulminant hepatic fail...

Human toxicity Digoxin is a very toxic compound, with an estimated lethal dose being only a few milligrams. Nausea and vomiting are early signs of acute digoxin toxicity. Among other symptoms are gastro-intestinal tract (GIT) disorders, abdominal pain, diarrhea, hyperkalemia, and muscle pain and weakness. Since digoxin is a cardiac medicine, its overdoses can have severe and multiple effects on...

Gastro-intestinal (GI) toxicity is the common adverse effect which has been associated with most of NSAIDs available in the market. So the search for new therapeutic agents with high margin of safety and freedom from normally associated GI toxic effects has been a priority of pharmacologists and pharmaceutical industries. There are virtually limitless series of structurally novel heterocyclic c...

La falta de pérdida peso o la re-ganancia postoperatoria, en el by pass gastrico, es un fenomeno que ocurre porcentaje significativo los pacientes, puede indicar desarrollo una dilatación anastomosis gastro-yeyunal, no restringe adecuadamente ingesta alimentos. Hay evidencia muestra diametro gastro-yeyunal se correlaciona positivamente con reganancia peso.La recalibración endoscópica gastro-yey...

BACKGROUND The primary objective of this study was to determine the maximum tolerated dose (MTD) of escalating doses of radiotherapy (RT) concomitantly with a fixed dose of gemcitabine (300 mg/m2/week) within the same overall treatment time. METHODS Thirteen patients were included. Gemcitabine 300 mg/m2/week was administered prior to RT. The initial dose of RT was 45 Gy in 1.8 Gy fractions, e...

The oral route is the best and most popular for administration of drugs in systemic circulation. There are number which given through route. Gastro-retentive drug delivery system very important system. gastro-retentive prolonged time git also improve their bioavailability. These widely used site specific treatment disorders diseases. approaches gastro retentive such as floating system, mucoadhe...

AIMS The primary aim was to assess whether there were differences in symptoms, laboratory data, and oesophageal pH-metry between infants with primary gastro-oesophageal reflux and those with reflux secondary to cows' milk protein allergy (CMPA). PATIENTS AND METHODS 96 infants (mean(SD) age 7.8(2.0) months) with either primary gastro-oesophageal reflux, reflux with CMPA, CMPA only, or none of...