OBJECTIVE Cod liver oil is used widely as a dietary supplement. The present study was carried out to evaluate the effect of cod liver oil (0.5 g/kg, p.o. and 1 g/kg, p.o.) on gastric and duodenal ulcers. MATERIALS AND METHODS The study was carried out on different gastric ulcer models such as acetic acid induced chronic gastric ulcers, pylorus ligation, indomethacin induced ulcers, stress ind...

Gum arabic is used throughout the world for various purposes including food additive and pharmaceutical excipient. The present study was undertaken to determine the effect of gum arabic on gastric ulcers in rats. The influence of gum arabic on the antiulcer activity of ranitidine, a known antiulcer drug was also evaluated. The antiulcer study was carried out in acetic acid induced chronic gastr...

BACKGROUND Two major causes of gastric ulcers are Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) use. AIMS This study aimed to determine if there were different expressions of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) between H. pylori-infected and NSAID-related ulcers. METHODS The 126 gastric ulce...

Gastric endoscopy was performed in the 24 Persian Arab horses from several race training in Tehran and Tabriz for detection of gastric ulcer. Gastric ulcer was evident in 14 Persian Arab horses (58.3%). Ten out of 14 ulcers were in nonglandular region of the stomach. The horses with the history of long term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) had high prevalence of the...

Prevalence of equine gastric ulcer syndrome in 85 young Thoroughbreds was investigated. The presence of gastric ulcers was confirmed in 27.1% (23/85) of the horses by endoscopic examination. Sixty-two horses without gastric ulcers were allocated randomly to either the treated group (31 horses) or sham-dosed control group (31 horses) in order to investigate the efficacy of omeprazole oral paste ...

aloe buettneri a. berger is commonly used in traditional togolese medicine to treat inflammatory and gastric ulcers. the present study examined the gastro-protection effect of the hydro-alcoholic extract of a. buettneri on mucus production and gastric ph. a gastric ulcer is induced by ethanol 95° alone (1 ml/kg body weight), after pre-treatment with indomethacin (300 mg/kg) or by utilising l-na...

gastric endoscopy was performed in the 24 persian arab horses from several race training in tehran and tabriz for detection of gastric ulcer. gastric ulcer was evident in 14 persian arab horses (58.3%). ten out of 14 ulcers were in nonglandular region of the stomach. the horses with the history of long term treatment with non-steroidal anti-inflammatory drugs (nsaids) had high prevalence of the...

The effect of extirpation of the submandibular glands, an exocrine organ for epidermal growth factor/urogastrone (EGF/URO), and the effect of oral administration of synthetic human (EGF/URO) on healing of chronic gastric ulcers in rats has been investigated. Removal of the submandibular glands delayed healing of chronic gastric ulcers when examined after 50, 100, and 200 days. Oral administrati...

The ingestion of non-steroidal anti-inflammatory drugs (NSAID) in 272 patients with bleeding or perforated peptic ulcer was compared with 272 age/sex matched controls. A significantly higher proportion of patients with gastric ulcers had received NSAID than those with duodenal ulcers. Twelve of 90 (13%) patients admitted with bleeding duodenal ulcers had received NSAID compared with 11 of 26 (4...