Background: Long noncoding RNAs (lncRNAs), as non-protein coding transcripts, play key roles in tumor progression and stemness state in many malignancies, as their aberrant expression has been found in gastric cancer (GC) as one of the most common cancer worldwide. LINC-ROR (large intergenic noncoding RNA regulator of reprogramming) identified as an involved lncRNA in human malignancies, howeve...

Gastric cancer (GC) is the fourth most common malignancy diagnosis and the second leading cause of cancer related mortalities worldwide. The role of SOX1 has been explored in several human cancers. However, its effects in gastric cancer have never been reported. In our study, we investigated the expression level of SOX1 and its biological function in GC. Firstly, we found that SOX1 is down-regu...

Summary Gastric cancer is the fifth most common and third leading cause of death worldwide. Patients with chronic atrophic gastritis (CAG) intestinal metaplasia (IM) are at increased risk developing gastric (GC). It for CAG to precede IM, but etiology two conditions not always same. Different scoring systems used assess HAG, MI, GC risk, making it difficult interpret results from investigations...

BACKGROUND Gastric premalignant conditions, atrophic gastritis (AG) and intestinal metaplasia (IM) are characterized by an increase of proliferation and a reduction of apoptosis in epithelial cells. The epithelial cell kinetics in AG and IM in gastric mucosa adjacent to gastric cancer is still unclear. The aim of this study was to evaluate the epithelial cell turnover and expression of prolifer...

Gastric cancer (GC) is an important health problem despite the advances in surgery and chemotherapy and although the incidence is decreasing, GC is still considered the second most common cause of deceases produced by cancer. Survival rates in gastric cancer are low, mainly because most patients are often diagnosed in late stages. The current interest in the diagnostic of GC is the detection of...

Objective: To investigate the biological significance of abundant miR-23a expression in gastric cancer (GC) and its correlation with PTEN in the pathogenesis of GC migration and invasion. Methods: The human gastric cancer cell lines SGC-7901, AGS, the immortalized cell line GES-1 derived from normal gastric mucosa. Cell transfection and selection of stable cell lines and the gene and protein le...

gastric cancer ( gc ) is the fifth most common cancer in the world and has the third highest mortality rates, for both sexes. in 2012, just fewer than 1,000,000 new cases of gc were diagnosed, and 723,000 deaths were attributable to it. helicobacter pylori ( h. pylori ) plays a predominant role in the aetiology of gc and was characterised as a class i carcinogen by the world health organisation...

Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter pylori (HP) seem to play important roles. The cytokine Interleukin-4 (IL-4) has effects in inflammation, allergies and cancer including GC. The association of IL-4 -590 C>T polymorphism a...

Cancer-associated mesenchymal stem cells (MSCs) are critically involved in tumor development and progression. However, the mechanisms of action for MSCs in cancer remain largely unknown. Herein, we reported that the expression of Yes-associated protein 1 (YAP) was higher in gastric cancer derived mesenchymal stem cells (GC‑MSCs) than that in bone marrow derived MSCs (BM‑MSCs). YAP knockdown not...

Gastric Cancer (GC) is the fifth leading cancer in world and third cause of cancer-related death. The 5-year survival rate advanced gastric less than 30%, it very important to prevent cancer. Current methods are eradication H. pylori, early endoscopic diagnosis treatment. Chemoprevention using natural, synthetic, or biological substances prevent, reverse development cancer, thereby reducing inc...