نتایج جستجو برای: gamma release tests

تعداد نتایج: 658394  

2016
Robert Koch

Abstract—Tuberculosis (TB) is a potentially serious infectious disease that remains a health concern. The Interferon Gamma Release Assay (IGRA) is a blood test to find out if an individual is tuberculous positive or negative. This study applies statistical analysis to the clinical data of interferon-gamma levels of seventythree subjects who diagnosed pulmonary TB in an anti-tuberculous treatmen...

2017
Alvaro Roy María A. Risalde Carmen Casal Beatriz Romero Lucía de Juan Ahmed M. Menshawy Alberto Díez-Guerrier Ramon A. Juste Joseba M. Garrido Iker A. Sevilla Christian Gortázar Lucas Domínguez Javier Bezos

Vaccination against tuberculosis (TB) is prohibited in cattle or other species subjected to specific TB eradication campaigns, due to the interference that it may cause with the official diagnostic tests. However, immunization with a heat-inactivated (HI) Mycobacterium bovis vaccine via the oral route has been suggested to overcome this issue. In this study, the main goal was to assess the inte...

2013
A. Trajman R. E. Steffen D. Menzies

A profusion of articles have been published on the accuracy and uses of interferon-gamma releasing assays. Here we review the clinical applications, advantages, and limitations of the tuberculin skin test and interferon-gamma release assays and provide an overview of the most recent systematic reviews conducted for different indications for the use of these tests. We conclude that both tests ar...

Journal: :Clinical and diagnostic laboratory immunology 2005
Neil M Ampel Daniel K Nelson Suzette Chavez Kathryn A Naus Amanda B Herman Lijin Li Keira A Simmons Demosthenes Pappagianis

Assessment of the cellular immune response in coccidioidomycosis has epidemiologic and prognostic importance. Measurement of delayed-type hypersensitivity to skin testing has been used in the past to determine cellular immunity in coccidioidomycosis. However, no skin tests are currently available in the United States. Assay of gamma interferon (IFN-gamma) release in whole blood in response to i...

2012
Silvan M. Vesenbeckh Nicolas Schönfeld Harald Mauch Thorsten Bergmann Sonja Wagner Torsten T. Bauer Holger Rüssmann

Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium tuberculosis infection. They cannot differentiate between latent and active infections. The cutoff suggested by the manufacturer is 0.35 IU/mL for latent tuberculosis. As IGRA tests were recently approved for the differential diagnosis of active tuberculosis, we assessed the diagnost...

Journal: :PLoS ONE 2008
Tom G. Connell Nicole Ritz Georgia A. Paxton Jim P. Buttery Nigel Curtis Sarath C. Ranganathan

BACKGROUND There are limited data comparing the performance of the two commercially available interferon gamma (IFN-gamma) release assays (IGRAs) for the diagnosis of tuberculosis (TB) in children. We compared QuantiFERON-TB gold In Tube (QFT-IT), T-SPOT.TB and the tuberculin skin test (TST) in children at risk for latent TB infection or TB disease. METHODS AND FINDINGS The results of both IG...

Journal: :The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2017
M Usdin M Dedicoat R Gajraj P Harrison H Kaur K Duffield C-L Walker Y Akram V Aiyedun H Mohamed D Zenner

SETTING England's national tuberculosis (TB) strategy recommends testing for and treatment of latent tuberculous infection (LTBI) among new migrants. Programmatic testing occurs in primary care, which may be inaccessible for some individuals. Current strategies could therefore be complemented by screening in other settings. OBJECTIVE To investigate the feasibility and effectiveness of LTBI sc...

Journal: :Japanese journal of infectious diseases 2011
Kiyoko Takayanagi Misako Aoki Kumiko Aman Satoshi Mitarai Nobuyuki Harada Kazue Higuchi Masao Okumura Takashi Yoshiyama Hideo Ogata Toru Mori

The reported effect of anti-tuberculosis chemotherapy on interferon-gamma (IFN-γ) release in response to specific Mycobacterium tuberculosis antigens has been inconsistent. The objective of this study was therefore to determine the effect of anti-tuberculosis chemotherapy on IFN-γ response to ESAT-6 and CFP-10. QuantiFERON®-TB Gold (QFT-G) was performed, and the IFN-γ response to ESAT-6 and CFP...

Journal: :The European respiratory journal 2011
I Abubakar T Matthews D Harmer E Okereke K Crawford T Hall T Collyns G Smith A Barrett S Baugh

The study population consisted of students enrolled at the college for daytime courses. All participants were aged .16 yrs. Members of staff who directly taught these students were also screened. Between October 2008 and December 2009, students, friends of the index case and staff at the college were interviewed. The interviews were used to collect demographic and clinical information, includin...

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