Carbon quantum dots assembled with gambogic acid via a π–π stacking interaction for cancer therapy have high drug loading and targeted delivery, which can overcome resistance, short circulation, retention in cells, thereby exhibiting significant inhibitory effect on the growth of HepG2 HeLa cells. This is reported by Jianfeng Wang co-workers article number 2200201.

Osteosarcoma is a common cancer type among the youth population and usually develops in growing bones. Approximately twenty percent of osteosarcoma cases show tendency to metastases patients with have low survival rate after treatment. RANK/RANKL/OPG key regulator triad bone remodeling play critical roles tumourigenesis osteosarcoma. Anti-proliferative activity gambogic acid was determined Saos...

10.1016/S1674-6384(17)60074-1 Objective To establish a quality control method for simultaneous determination of multiple components in gamboge. Methods A single reference standard for the determination of multiple components (SSDMC) with HPLC was proposed. Seven major components of gamboge including gambogenic acid (S), β-morellic acid (C1), 2R-30-hydroxygambogic acid (C2), isogambogenic acid ...

Nerve growth factor (NGF) binds to TrkA receptor and triggers activation of numerous signaling cascades, which play critical roles in neuronal plasticity, survival, and neurite outgrowth. To mimic NGF functions pharmacologically, we developed a high-throughput screening assay to identify small-molecule agonists for TrkA receptor. The most potent compound, gambogic amide, selectively binds to Tr...