nucleostemin (ns), a stem cell-abundant nucleolar protein, is critical for maintaining the self-renewal and proliferative properties of normal and cancerous stem cells. recent data suggests that ns signaling is important for proliferation of t-cells and leukemia cells. this study was conducted to verify the role of ns in pathogenesis and treatment of t-cell acute lymphocytic leukemia (t-all). o...

BACKGROUND Plant-derived cardenolides reportedly possess anticancer properties in human leukemic cells via selective induction of apoptosis, cell cycle arrest, and differentiation. Selective induction of apoptosis with mammalian-derived digoxin-like immunoreactive factor (DLIF) could provide new strategies for anticancer drug development or the identification of biomarkers for cancer. We invest...

The inhibitory effect of microRNA (miR)-325 in multiple different types cancer cell has been identified; however, its biological function T acute lymphoblastic leukemia (T-ALL) remains unknown. Moreover, Bcl-2-associated athanogene (BAG)2 is highly expressed a various tumors and regarded as an anti-apoptotic gene. In the present study, roles miR-325 BAG2 T-ALL line (Jurkat cells) were investiga...

Background: Leukemia remains a global health challenge, requiring the exploration of alternative therapies with reduced side effects. Probiotics, particularly Lactobacillus species, have gained attention because their potential anticancer properties. This study investigated and cytotoxic effects postbiotic mediators (PMs) derived from rhamnosus GG (LGG) reuteri (LR) on acute lymphoblastic leuke...

The present study aimed to investigate the role of microRNA (miR)-101 in acute lymphoblastic leukemia progression and chemoresistance. Furthermore, a novel target gene of miR-101 was identified. Here, we confirmed that miR-101 was significantly downregulated in the blood samples of patients with T-cell acute lymphoblastic leukemia (T-ALL) compared with the healthy controls, as determined by rev...

acute lymphoblastic leukemia (all) is the most prevalent hematological malignant tumor during childhood. unilateral infiltration into the gums is less prevalent and more often observed in the aml type. a 12-year-old girl with symptoms of pain and swelling in the buccal vestibule and also at the posterior part of the right palate of the maxilla was referred to a private dental office. the patien...

Ginsenoside Rh2 (GRh2) and ginsenoside Rg3 (GRg3) are primary bioactive components in Panax ginseng. The present study aimed to investigate the underlying mechanisms of apoptotic cell‑death induced by GRh2 and GRg3 in human leukemia Jurkat cells. The Cell Counting kit‑8 assay was used to determine cell proliferation. Apoptosis was detected by nuclear morphologic observation by Hoechst 33342 sta...

chronic lymphocytic leukemia (cll) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. many ferula species, including f. asa-foetida, synthesize terpenyloxy coumarins. one of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     in this study induction of apoptosis by umbelliprenin ...