نتایج جستجو برای: galectin

تعداد نتایج: 4550  

Journal: :dental research journal 0
thais ayako hossaka daniel a ribeiro gustavo focchi sabine andré mariana fernandes fernando cintra lopes carapeto

back ground: the aim of this study was to characterize the immunohistochemical expression of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma. materials and methods: immunohistochemical staining for galectins 1, 3, and 9 was evaluated in 8 samples of normal oral squamous epithelium, 15 samples of oral squamous papilloma, and 41 samples of...

2016
Hyeok Gu Kang Da-Hyun Kim Seok-Jun Kim Yunhee Cho Junghyun Jung Wonhee Jang Kyung-Hee Chun

Ovarian cancer is the most lethal gynecologic disease because usually, it is lately sensed, easily acquires chemoresistance, and has a high recurrence rate. Recent studies suggest that ovarian cancer stem cells (CSCs) are involved in these malignancies. Here, we demonstrated that galectin-3 maintains ovarian CSCs by activating the Notch1 intracellular domain (NICD1). The number and size of ovar...

Journal: :Glycobiology 2010
Joana Tavares de Oliveira Augusto Jf de Matos Joana Gomes Manuel Vilanova Venceslau Hespanhol Aki Manninen Gerard Rutteman Roger Chammas Fátima Gärtner Emerson Soares Bernardes

Galectin-3 is a glycan-binding protein that mediates cell-cell and/or cell-extracellular matrix (ECM) interactions. Although galectin-3 is implicated in the progression of various types of cancers, the mechanisms by which galectin-3 enhances metastasis remain unclear. In order to elucidate the role of galectin-3 in the complex multistage process of cancer metastasis, we examined galectin-3 and ...

Journal: :The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009
Junko Nio-Kobayashi Hiromi Takahashi-Iwanaga Toshihiko Iwanaga

Galectin, an animal lectin that recognizes beta-galactoside of glycoconjugates, is abundant in the gut. This IHC study showed the subtype-specific localization of galectin in the mouse digestive tract. Mucosal epithelium showed region/cell-specific localization of each galectin subtype. Gastric mucous cells exhibited intense immunoreactions for galectin-2 and galectin-4/6 with a limited localiz...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2012
Nathalie Saint-Lu Beatrijs D Oortwijn Julie N Pegon Soline Odouard Olivier D Christophe Philip G de Groot Cécile V Denis Peter J Lenting

OBJECTIVE Although von Willebrand factor (VWF) is a heavily glycosylated protein, its potential to associate with glycan-binding proteins is poorly investigated. Here, we explored its interaction with the glycan-binding proteins galectin-1 and galectin-3. METHODS AND RESULTS Immunofluorescence analysis using Duolink proximity ligation assays revealed that VWF colocalizes with galectin-1 and g...

2017
KeeSoo Nam Seog-ho Son Sunhwa Oh Donghwan Jeon Hyungjoo Kim Dong-Young Noh Sangmin Kim Incheol Shin

Galectin-1 is a β-galactoside binding protein secreted by many types of aggressive cancer cells. Although many studies have focused on the role of galectin-1 in cancer progression, relatively little attention has been paid to galectin-1 as an extracellular therapeutic target. To elucidate the molecular mechanisms underlying galectin-1-mediated cancer progression, we established galectin-1 knock...

2017
Yan-Chu Chen Yun-Li Ma Cheng-Hsiung Lin Sin-Jhong Cheng Wei-Lun Hsu Eminy H.-Y. Lee

Galectin-3, a member of the galectin protein family, has been found to regulate cell proliferation, inhibit apoptosis and promote inflammatory responses. Galectin-3 is also expressed in the adult rat hippocampus, but its role in learning and memory function is not known. Here, we found that contextual fear-conditioning training, spatial training or injection of NMDA into the rat CA1 area each d...

2016
Khuchtumur Bum-Erdene Hakon Leffler Ulf J. Nilsson Helen Blanchard

Galectin-4 is a tandem-repeat galectin with two distinct carbohydrate recognition domains (CRD). Galectin-4 is expressed mainly in the alimentary tract and is proposed to function as a lipid raft and adherens junction stabilizer by its glycan cross-linking capacity. Galectin-4 plays divergent roles in cancer and inflammatory conditions, either promoting or inhibiting each disease progression, d...

2012
Nathalie Saint-Lu Beatrijs D. Oortwijn Julie N. Pegon Soline Odouard Olivier D. Christophe Philip G. de Groot Cécile V. Denis Peter J. Lenting

Objective—Although von Willebrand factor (VWF) is a heavily glycosylated protein, its potential to associate with glycan-binding proteins is poorly investigated. Here, we explored its interaction with the glycan-binding proteins galectin-1 and galectin-3. Methods and Results—Immunofluorescence analysis using Duolink proximity ligation assays revealed that VWF colocalizes with galectin-1 and gal...

2018
Jingxin Zhang Guodong Deng Lili Qiao Hui Luo Qiqi Liu Ning Liang Jian Xie Jiandong Zhang

Galectin-3 is a multifunctional β-galactoside binding lectin associated with tumor progression. Previous studies confirmed the roles of galecin-3 overexpression and silencing in the biological behavior of Eca109 human esophageal cancer (EC) cells; galectin-3 may serve a critical role in the vasculogenic mimicry (VM) of tumors. Therefore, the present study examined the effects of galectin-3 knoc...

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