the present study , was an attempt to develop galactosylated albumin nanoparticles of simvastatin for treatment of hypercholesterolemia. by developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. the advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to t...

Background: Curcumin is the most active ingredient in turmeric root of Curcuma longa of the Zingiberaceae family and has a potent antioxidant activity. This study aimed at investigating the effects of curcumin with various doses on the density of dark neurons in the hippocampus of induced D-galactose aging mice model. This experimental study was conducted on 40 adult male BALB/c mice.  Materia...

in the present study a new economic and rapid bacterial micro-assay for simultaneous detection and quantitative measurement of serum galactose was developed. analysis of the standard curve showed a linearity range for galactose from 2 mg/dl to 180 mg/dl with a regression equation of y = 0.013x ? 0.083; r² = 0.962. the advantage of the method is its ability to measure serum galactose quantitativ...

  Objective(s): In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice.   Materials and Methods: Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/kg/day for 6 weeks). A positive control group was assigned...

Background and Objective: Aging is a natural phenomenon which can cause changes in most organs and cells. Numerous mechanisms including oxidative stress and free radical generation is involved in the progression of the aging process. Pomegranate seed oil (PSO), has different therapeutic properties including anti-oxidant and anti-inflammatory effects. In this research, the effect of PSO against ...

  Background: Increased oxygen free radical and reduced glutathione level in the eye lens are important risk factor for cataract formation. The antioxidative property and increasing cellular and extra cellular glutathione level have been reported by several herbal medicines including silymarin.  Objective: In present interventional study Silybum marianum L. seed extract (silymarin) was tested a...

The present study aimed to evaluate the sensitivity and specificity of fucose some biochemical parameters, as an indicator therapeutic response Metformin in patients with recently diagnosed Polycystic Ovary Syndrome-PCOS undergoing treatment. This was conducted from 1/9/2022 1/11/2022. In 90 blood samples were collected women aged between (35-18) years old. Of these, 30 taken who had been polyc...

In order to investigate the mechanism of inactivation of the galactose-fermenting system (“galactozymase”) after addition of glucose to galactose-grown cells of Saccharomyces cereuisiae the activities of the following enzymes of galactose utilization were assayed: the galactose uptake system, galactokinase, galact,ose-l-phosphate uridyltransferase, UDP-galactose-4-epimerase, and phosphoglucomut...

background: increased oxygen free radical and reduced glutathione level in the eye lens are important risk factor for cataract formation. the antioxidative property and increasing cellular and extra cellular glutathione level have been reported by several herbal medicines including silymarin.  objective: in present interventional study silybum marianum l. seed extract (silymarin) was tested aga...

This study of galactose-induced galactose transport in Escherichia coli K12 showed that in most strains two transport systems having the properties of “galactose permease” and “P-methyl galactoside permease” are responsible for the observed transport. Several strains contain only the galactose transport system but still grow normally on galactose. The regulation of this system was shown to be v...