Human melanoma MZ2-MEL expresses several distinct antigens that are recognized by autologous cytolytic T lymphocytes (CTL). Some of these antigens are encoded by genes MAGE-1, MAGE-3, and BAGE, which are expressed in a large fraction of tumors of various histological types but are silent in normal adult tissues with the exception of testis. We report here the identification of the gene coding f...

For the past 30 years, the study ofaccuracy in person perception has been a neglected topic in social and personality psychology. Research in this area was stopped by a critique of global accuracy scores by Cronbach and Gage. They argued that accuracy should be measured in terms of components. Currently, interest in the topic of accuracy is rekindling. This interest is motivated, in part, by a ...

For a number of years, "process-product" re searchers have studied the relationship between teacher behaviors (process) and student achievement (product) with the hope of determining what teacher behaviors will lead to increases in student achieve ment and attitude. At last, this research has borne fruit. Several reviewers of process-product research have recently concluded that effective teach...

The GAGE family of tumor-associated antigens is present in a wide spectrum of human tumors but is highly restricted among normal tissues except to the testis. By reverse transcription-PCR, GAGE expression was detected in 55 of 67 neuroblastomas (NBs; 8 of 12 stage 1, 13 of 13 stage 2, 9 of 12 stage 3, 7 of 12 stage 4S, and 18 of 18 stage 4), 5 of 5 Ewing's and peripheral neuroectodermal tumors,...

The need for calibration arises frequently in the use of strain gage instrumentation. Periodic calibration is required, of course, to assure the accuracy and/or linearity of the instrument itself. More often, calibration is necessary to scale the instrument sensitivity (by adjusting gage factor or gain) in order that the registered output correspond conveniently and accurately to some predeterm...

With the advent of rapid genome sequencing, the view of the human genome as a vast desert dotted with far-flung oases of functional genes has contended with a growing appreciation of the role of regulatory sequences in shaping gene expression. The fraction of the human genome’s noncoding component that can be considered functional remains to be established, but strewn across the seeming wastela...

The calculation of uncertainty for a measurement is an effort to set reasonable bounds for the measurement result according to standardized rules. Since every measurement produces only an estimate of the answer, the primary requisite of an uncertainty statement is to inform the reader of how sure the writer is that the answer is in a certain range. This report explains how we have implemented t...

Perhaps the most famous brain injury in history was a penetrating wound suffered by a rail road worker named Phineas Gage on September 13, 1848. Twelve years after his injury, on the 21st of May, 1860 Phineas Gage died of an epileptic seizure. In 1868 Dr. Harlow gave an outline of Gage's case history and first disclosed his remarkable personality change. One might think this report would assure...

BACKGROUND Cancer/testis antigens (CTAs) are expressed in several cancers and during normal adult male germ cell differentiation. Little is known about their role in fetal development of human germ cells. METHODS We examined expression of the CTAs MAGE-A1, GAGE and NY-ESO-1 in fetal gonads by single and double immunohistochemical staining. RESULTS We found that GAGE was expressed in the pri...