Investigations of the boundary between generalized anxiety disorder (GAD) and normal worry have relied primarily on comparisons of GAD-diagnosed individuals with non-anxious controls. One limitation of this approach has been its inability to determine whether characteristics associated with GAD are unique to the disorder or are typical of severe worry more generally. The present studies made th...

OBJECTIVE To analyse the prevalence of GAD and other anxiety disorders, as well as sensitivity and specificity of GAD-7 among high utilizers of health care. SETTING Four municipal health centres in Northern Finland. SUBJECTS A psychiatric interview was conducted for 150 high utilizers of health care. MAIN OUTCOME MEASURES Prevalence of GAD as well as sensitivity and specificity of GAD-7. ...

high comorbidity between psychological disorders causes attention to the mechanisms responsible for this comorbidity and common cognitive factors involved in these disorders. these are known as transdiagniostic factors. similarity evidence and high comorbidity between generalized anxiety disorder (gad) and obsessive compulsive disorder (ocd) introduce them as neighboring disorders. the purpose ...

Little is known about the role of anger in the context of anxiety disorders, particularly with generalized anxiety disorder (GAD). The aim of study was to examine the relationship between specific dimensions of anger and GAD. Participants (N=381) completed a series of questionnaires, including the Generalized Anxiety Disorder Questionnaire (GAD-Q-IV; Newman et al., 2002, Behavior Therapy, 33, 2...

Glutamic acid decarboxylase (GAD) is the enzyme that synthesizes the neurotransmitter gamma-aminobutyric acid (GABA) in neurons and in pancreatic beta cells. It is a major target of autoimmunity in Stiff-Man syndrome (SMS), a rare neurological disease, and in insulin-dependent diabetes mellitus. The two GAD isoforms, GAD-65 and GAD-67, are the products of two different genes. GAD-67 and GAD-65 ...

BACKGROUND Generalized anxiety disorder (GAD) is the most frequent anxiety disorder in primary care patients. It is known that painful physical symptoms (PPS) are associated with GAD, regardless the presence of comorbid major depressive disorder (MDD). However the specific role of such symptoms in patients' functional impairment is not well understood. The objective of the present study is to a...

A phase II clinical trial with glutamic acid decarboxylase (GAD) 65 formulated with aluminium hydroxide (GAD-alum) has shown efficacy in preserving residual insulin secretion in children and adolescents with recent-onset type 1 diabetes (T1D). We have performed a 4-year follow-up study of 59 of the original 70 patients to investigate long-term cellular and humoral immune responses after GAD-alu...

Glutamic acid decarboxylase (GAD) is an enzyme which converts the glutamic acid to the neurotransmitter gamma-amino butyric acid (GABA). GABA is an inhibitory neurotransmitter that inhibits or weakens the neuronal stimulations. Presynaptic GABAergic neurons in the central neurons system (CNS) and the cells in the islets of Langerhans in the pancreas generate GAD. There are two isoforms of GAD n...