نتایج جستجو برای: fxiii 100 gt polymorphism

تعداد نتایج: 586334  

Journal: :The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2011
Mahmoud Aarabi Toktam Memariani Soheila Arefi Mohsen Aarabi Sedigheh Hantoosh Zadeh Mehdi A Akhondi Mohammad H Modarressi

We investigated polymorphisms of plasminogen activator inhibitor-1 (PAI-1), angiotensin converting enzyme (ACE ) and coagulation factor XIII (FXIII) genes and their association with recurrent spontaneous abortion (RSA) in Iranian patients and normal healthy controls. Ten (18.5%) patients were homozygote (4G/4G) for PAI-1 polymorphism, in contrast with two (2%) controls (p = 0.001). Patients wit...

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2015
Zoltán A. Mezei Zsuzsanna Bereczky Éva Katona Réka Gindele Emília Balogh Szilvia Fiatal László Balogh István Czuriga Róza Ádány István Édes László Muszbek

The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII) B subunit (FXIII-B) polymorphisms on the risk of coronary artery disease, and on FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classi...

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Journal: :Thrombosis research 2010
Robert Carreras-Torres Georgios Athanasiadis Marc Via Joan Trenchs Magdalena Gayà-Vidal Josep Santamaria Esther Esteban Pedro Moral

Atherothrombotic diseases are a group of diseases that cause the majority of population morbidity in industrialized countries. Genetic variation in causative or susceptible genes constitutes the basis of molecular mechanisms, that together with environmental factors, lead to disease development [1]. Plasma coagulation factor XIII (FXIII) is a pro-transglutaminase essential for haemostasis which...

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Journal: :Arteriosclerosis, thrombosis, and vascular biology 2016
Cédric Duval Majid Ali Waleed W Chaudhry Victoria C Ridger Robert A S Ariëns Helen Philippou

OBJECTIVE Factor XIII (FXIII) cross-links fibrin upon activation by thrombin. Activation involves cleavage at residue 37 by thrombin, releasing an activation peptide. A common polymorphism (valine to leucine variant at residue 34, V34L), located in the activation peptide, has been associated with increased activation rates and paradoxically a protective effect in cardiovascular disease. There i...

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Journal: :iranian journal of pediatric hematology and oncology 0
shima kazemzadeh department of laboratory hematology and blood banking, faculty of allied medicine, kerman university of medical sciences rezvan mohammadi pathology and stem cell research center, kerman university of medical sciences, kerman, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (kerman university of medical sciences) fatemeh shadkam farokhi pathology and stem cell research center, kerman university of medical sciences, kerman, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (kerman university of medical sciences) alireza shafiian school of veterinary medicine, shahid bahonar university of kerman, kerman, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (kerman university of medical sciences) mohammad faranoush pediatric growth and development research center, endocrinology institute, iran university of medical science, tehran,سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (kerman university of medical sciences) alireza farsinejad pathology and stem cell research center, kerman university of medical sciences, kerman, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

background: the most common polymorphisms identified in the methylenetetrahydrofolate reductase (mthfr) gene, c677t and a1298c lead to defective activity of this enzyme and increase the risk of venous and arterial thrombosis. there are limited investigations regarding the effects of thrombogenic polymorphisms on the clinical phenotypes of rare hereditary hemorrhagic disorders like glanzmann's t...

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Journal: :Haematologica 2000
R F Franco A Pazin-Filho M H Tavella M V Simões J A Marin-Neto M A Zago

BACKGROUND AND OBJECTIVE Recent studies have suggested an association between a genetic variation in the coagulation factor XIII (FXIII Val34Leu) and decreased risk of vascular thrombosis. DESIGN AND METHODS We investigated the frequency of the FXIII Val34Leu polymorphism in 150 consecutive, unrelated and relatively young (<55 years) survivors of myocardial infarction (MI) with angiographical...

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Journal: :Blood 2000
I Balogh G Szôke L Kárpáti U Wartiovaara E Katona I Komáromi G Haramura G Pfliegler H Mikkola L Muszbek

Val34Leu polymorphism of the A subunit of coagulation factor XIII (FXIII-A) is located in the activation peptide (AP) just 3 amino acids away from the thrombin cleavage site. This mutation has been associated with a protective effect against occlusive arterial diseases and venous thrombosis; however, its biochemical consequences have not been explored. In the current study it was demonstrated t...

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Journal: :Blood 2000
R A Ariëns H Philippou C Nagaswami J W Weisel D A Lane P J Grant

Factor XIII on activation by thrombin cross-links fibrin. A common polymorphism Val to Leu at position 34 in the FXIII A subunit is under investigation as a risk determinant of thrombosis. Because Val34Leu is close to the thrombin cleavage site, the hypothesis that it would alter the function of FXIII was tested. Analysis of FXIII subunit proteolysis by thrombin using sodium dodecyl sulfate-pol...

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Journal: :Stroke 2001
M Weger W Renner O Stanger O Schmut H Deutschmann T C Wascher A Haas

BACKGROUND AND PURPOSE Factor XIII (FXIII) Val34Leu, a common polymorphism in the gene for factor XIII, has been associated with a lower risk of stroke, myocardial infarction, and deep vein thrombosis. Ineffective fibrin cross-linking has been suggested to be causative. The aim of the present case-control study was to investigate the role of FXIII Val34Leu polymorphism in patients with retinal ...

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2000
István Balogh Gabriella Szôke Levente Kárpáti Ulla Wartiovaara Éva Katona István Komáromi Gizella Haramura György Pfliegler Hanna Mikkola László Muszbek

Val34Leu polymorphism of the A subunit of coagulation factor XIII (FXIII-A) is located in the activation peptide (AP) just 3 amino acids away from the thrombin cleavage site. This mutation has been associated with a protective effect against occlusive arterial diseases and venous thrombosis; however, its biochemical consequences have not been explored. In the current study it was demonstrated t...

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