Exosomes are extracellular membrane vesicles whose biogenesis by exocytosis of multivesicular endosomes was discovered in 1983. Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discuss the initial experiments that led to the discovery of exosomes and highlight some of the excitin...

in spite of considerable increase in the resolution of general circulation and regional models, none of these models are capable to predict and downscale the meteorological outputs in the scale of meteorological station.in this regard, different dynamical and statistical models have been developed for downscaling outputs of gcms. in this paper, grided meteorological outputs of general circulati...

Reliable forecasts of climate change in the immediate future are difficult, especially on regional scales, where natural climate variations may amplify or mitigate anthropogenic warming in ways that numerical models capture poorly. By decomposing recent observed surface temperatures into components associated with ENSO, volcanic and solar activity, and anthropogenic influences, we anticipate gl...

and obscures the secular increase in real expenditure on means-tested transfer programs taken as a whole. Indeed, Figure 1, which shows expenditures since 1968 in the 80 largest programs in the country, indicates that per-capita expenditure on means-tested programs is higher today than ever in its history. The enormous growth in real expenditure that occurred in the late 1960s and early 1970s, ...