نتایج جستجو برای: fugene6
تعداد نتایج: 14 فیلتر نتایج به سال:
Introduction Transplantation of embryonic stem cell derivatives is a promising therapeutic approach for heart failure. Current methods of studying stem cell engraftment rely heavily on postmortem histological sampling. This precludes longitudinal monitoring and hinders studies of biodistribution, survival and proliferation. Noninvasive MR imaging of grafted cells is possible through cell labeli...
-Secretase, exhibiting characteristics of aspartyl protease, mediates the intramembranous proteolysis of -amyloid precursor protein (APP) and Notch, and it is considered to be a prime pharmacological target in the development of therapeutics for Alzheimer’s disease (AD). To identify compounds that block -secretase-mediated proteolysis, we used a highly sensitive cell-based reporter gene assay f...
Activation of the inositol-requiring enzyme-1 alpha (IRE1a) protein caused by endoplasmic reticulum stress results in the homodimerization of the N-terminal endoplasmic reticulum luminal domains, autophosphorylation of the cytoplasmic kinase domains, and conformational changes to the cytoplasmic endoribonuclease (RNase) domains, which render them functional and can lead to the splicing of X-box...
Inhibitor of DNA binding 1 (Id-1) has been implicated in tumor angiogenesis by regulating the expression of vascular endothelial growth factor (VEGF), but its molecularmechanismhasnotbeen fully understood.Here, weshow the cross talk between Id-1 and hypoxia-inducible factor-1A (HIF-1A), that Id-1 induces VEGF by enhancing the stability and activity of HIF-1A in human endothelial and breast canc...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید