نتایج جستجو برای: fto
تعداد نتایج: 1986 فیلتر نتایج به سال:
Recently, genome-wide association studies have linked variations in alleles of the FTO (fat mass and obesity associated) gene to obesity. Gerken et al. (2007) now reveal that FTO encodes a nucleic acid demethylase. Upon examination of the sequence of FTO, the authors noticed a domain that had homology to 2-oxoglutarate oxygenases. These enzymes are involved in a variety of processes including D...
BACKGROUND Intrauterine and postnatal overnutrition program hyperphagia, adiposity and glucose intolerance in offspring. Single-nucleotide polymorphisms (SNPs) of the fat mass and obesity associated (FTO) gene have been linked to increased risk of obesity. FTO is highly expressed in hypothalamic regions critical for energy balance and hyperphagic phenotypes were linked with FTO SNPs. As nutriti...
Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in lethality and severe developmental defects. Despite intense scientific discussions around the role of FTO in energy metabolism, the function of FT...
Fat mass and obesity associated protein (Fto) is a nucleic acid demethylase, with a preference for thymine or uracil, according to the recent structural data. This fact suggests that methylated single-stranded RNA, rather than DNA, may be the primary Fto substrate. Fto is abundantly expressed in all hypothalamic sites governing feeding behavior. Considering that selective modulation of Fto leve...
OBJECTIVE Common variants in FTO (the fat mass- and obesity-associated gene) associate with obesity and type 2 diabetes. The regulation and biological function of FTO mRNA expression in target tissue is unknown. We investigated the genetic and nongenetic regulation of FTO mRNA in skeletal muscle and adipose tissue and their influence on in vivo glucose and fat metabolism. RESEARCH DESIGN AND ...
FTO (Fat mass and obesity-associated) is associated with increased risk of obesity and type 2 diabetes incurrence. Pancreas islet β cells dysfunction and insulin resistance are major causes of type 2 diabetes. However, whether FTO plays an important functional role in pancreatic β cells as well as the related molecular mechanism is still unclear. In the present study, the tissue expression prof...
The Fto gene was first cloned after identification of a Fused toe (Ft) mutant mouse, whose phenotype arised from a 1.6mb deletion of six genes, including Fto [1, 2]. FTO is a very large gene, also known as fat mass and obesity associated gene. In human, it is located on chromosome 16, consisting of 9 exons and spanning more than 400kb [3]. FTO mRNA is widely expressed in different tissues, espe...
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases. We find that recombinant murine Fto catalyzes the Fe(II)- and 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA, with concomitant prod...
abstract tuberculosis and diabetes mellitus are the most important reasons in mortality all over the world. it’s clear that reviewing of relationship between tuberculosis (tb) and diabetes mellitus (dm) is necessary; on the other hand it’s found that fto gene has the positive relationship with metabolic issues. therefore, it’s necessary pay attention to the above and dangerous sicknesses, espec...
The metabolic syndrome is a worldwide problem mainly caused by obesity. FTO was found to be a obesity-risk gene in humans and FTO deficiency in mice led to reduction in adipose tissue. Thus, FTO is an important factor for the development of obesity. Leptin-deficient mice are a well characterized model for analysing the metabolic syndrome. To determine the relevance of FTO for the development of...
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