Fructus Ligustri Lucidi is a well-known invigorator in Chinese materia medica with hepatoprotective effect, anticancer activity, antioxidant activity, and so on. And oleanolic acids are the major pharmacologically active components in Fructus Ligustri Lucidi. So it has great value in medical health, and may be developed to a complementary and alternative medicine through further research. In th...

high performance liquid chromatography (hplc) with diode array detection (dad) and electrospray ionization tandem mass spectrometry (esi/ms/ms) was used to analyze the main components in the methanol extract of fructus aurantii (fa) and the metabolites in rat biological samples after oral administration of the methanol extract of fa. there were 31 constituents identified in the extract of fa in...

weichang’an (wca) pill, a traditional chinese patent medicine consisting of ten chinese medicinal herbs, has been used to treat irritable bowel syndrome and functional dyspepsia for several decades. in this study, twelve bioactive constituents in the methanol extract of wca were accurately identified since ms/ms fragmentation behavior of the references and the standards by using hplc-dad-esi-ms...

We investigated the inhibition of advanced glycation endproduct (AGE) activity using the fluorescence characteristics of fractions and compounds from Corni Fructus. Corni Fructus extract and its iridoid glycoside components showed low inhibitory activities as well as the AGE inhibitor aminoguanidine. However, a low molecular weight polyphenol, 7-O-galloyl-D-sedoheptulose, and an antioxidant, tr...

This study investigated the antioxidative action of Corni Fructus aqueous extract on kidneys of diabetic mice. The electron donating abilities of Corni Fructus aqueous extract and its antioxidant activities (XO, SOD, CAT, GST, eNOS) in kidneys of C57BL/6 or db/db mice were evaluated. For in vivo study, seven week-old male mice were divided into normal control group (NC, C57BL/6 mice) , diabetic...

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Oxidative stress plays a large role in the pathogenesis of AMD. The present study was to evaluate the effects of Fructus lycii ethanol extract on AMD in mice and to investigate whether combination of lutein and zeaxanthin, two carotenoid pigments in Fructus lycii, could protect human retinal pigment epithelial ARPE-...

Weichang’an (WCA) pill, a traditional Chinese patent medicine consisting of ten Chinese medicinal herbs, has been used to treat irritable bowel syndrome and functional dyspepsia for several decades. In this study, twelve bioactive constituents in the methanol extract of WCA were accurately identified since MS/MS fragmentation behavior of the references and the standards by using HPLC-DAD-ESI-MS...

High performance liquid chromatography (HPLC) with diode array detection (DAD) and electrospray ionization tandem mass spectrometry (ESI/MS/MS) was used to analyze the main components in the methanol extract of Fructus Aurantii (FA) and the metabolites in rat biological samples after oral administration of the methanol extract of FA. There were 31 constituents identified in the extract of FA in...

This study was mainly to observe the anti-allergic effect of Fructus cnidii ethanol extract. Three methods were chose to observe the anti-allergic effect of Fructus cnidii including rat Passive Cutaneous Anaphylaxis (PCA) tests, rat skull periosteum mast cell degranulation tests, and histamine released factors in rat peritoneal mast cells sensitized mast cells with vitro techniques. The PCA inh...

BACKGROUND Fructus Corni is derived from the dry ripe sarcocarp of Cornus officinalis Sieb. et Zucc. 5-hydroxymethyl-2-furaldehyde (5-HMF) is an important active composition of the Fructus Corni. However, there have been no reports on the concentration of 5-HMF in freely moving rats using microdialysis coupled with HPLC. MATERIALS AND METHODS The concentration of 5-HMF in free-moving rats aft...