Case presentation: Female patient, 8 years old, born in Itanhaem, from São Paulo, with a previous context of hypotonic infant syndrome, repetitive head nodding movements, convergent strabismus, alopecia, low implantation the ears and short stature. On evaluation, he was alert, without language alterations, threshold for fructation, difficulty concentrating, hyperactivity, but evidence intellect...

A comprehensive in vitro study involving antiglycation, antioxidant and anti-diabetic assays was carried out in mature fruits of strawberry. The effect of aqueous extract of mature strawberry fruits on glycation of guanosine with glucose and fructose with or without oxidizing entities like reactive oxygen species was analyzed. Spectral studies showed that glycation and/or fructation of guanosin...

Specific functions have not been assigned to lens crystallins. It was assumed that they had been recruited to the lens to refract light. Mammali an aaystallin, which may represent up to 50% of the total crystallin [I], is sequentially related to heat shock proteins [2], with sauctural and functional similarities to the mouse small heat shock protein Hsp25 [3]. aB-Crystallin has been found outsi...

Rubia cordifolia Linn. a flowering plant species from family Rubiaceae is an important medicinal plant. It is known to have anti-diabetic, antiseptic and antistress properties. In the present paper, antiglycation, antioxidant and antidiabetic activities of roots of Rubia cordifolia Linn. were investigated. Anti-AGE (Advance glycation end products) effect of Rubia cordifolia Linn. on glycation o...

Advanced glycation end products (AGEs) may play an important adverse role in process of atherosclerosis, diabetes, aging and chronic renal failure. Levels of N(epsilon)-carboxymethyllysine and fluorescent AGE values were estimated in two nutritional population groups--alternative group (vegetarians--plant food, milk products, eggs) and traditional group (omnivorous subjects). Vegetarians have a...

Serum albumin is exposed to numerous structural modifications which affect its stability and activity. Glycation is one of the processes leading to the loss of the original properties of the albumin and physiological function disorder. In terms of long lasting states of the hyperglycemia, Advanced Glycation End-products (AGEs) are formed. AGEs are responsible for cellular and tissue structure d...