the physicochemical properties of Iranian acetyl salicylic acid(ASA) tablets,including the products of 10 manufacturers with 14 products,from each 3 batches,totally 42 products have been studied.the properties under investigation are hardness,friability percintage,humidity percentage,free salicylic acid,content uniformity,amount of ASA disintegration time,and released percentage.the results ind...

This study aimed to prepare tablets of black pepper extract using the Design Experiments (DOE) approach. The levels three factors—compressional force, croscarmellose sodium (CCS), and microcrystalline cellulose (MCC)—were screened one-factor-at-a-time technique, followed by DOE utilizing Box–Behnken design. respective variations for each factor were as follows: compressional force (1500–2500 ps...

Microcrystalline cellulose (MCC) and powdered cellulose (PC) are commonly used excipients for solid dosage forms e.g., pellets. The aim of this study was to compare the utility of the MCC and PC in the floating pellet cores comprising verapamil hydrochloride (VH) manufactured by extrusion and spheronization and influence on their physical properties like swelling, compressibility and VH release...

Objective: The aim of this study was to develop a tablet formulation of Wat Pho hypnotic formula, a classical Thai traditional hypnotic drug. In addition, a preformulation study and physical properties of the finished products were investigated to select the best formulation for further study. Methods: Tablets of the six formulations (D1-D6) were prepared by the direct compression method. The p...

The interchangeability between a generic and the respective reference drug is based on the concept of therapeutic equivalence between them, usually provided by evidence of pharmaceutical equivalence, bioequivalence, Good Manufacturing Practices (GMP), and quality control. This study aimed to evaluate the pharmaceutical equivalence between four brands of 500 mg aspirin tablets (two generic, G, a...

In the following study starch was isolated from the dried pulp of unripe pappaya fruit (Carica pappaya). The isolated starch was used as a binder in different concentrations in diclofenac sodium tablets. The tablets were formed by wet granulation method by using 2% w/v, 4% w/v, 6% w/v, 8% w/v and 10% w/v pappaya starch as binding agent. Formulated diclofenac sodium tablets were further evaluate...

The aim of this study was to develop orally disintegrated tablets (ODT) with loratadine using Parteck ODT and Ludiflash--new commercially available tableting excipients based on co-processed mannitol. ODT containing loratadine were prepared with 3% addition of various superdisintegrants (AcDiSol, Kollidon CL-F and Kollidon CL-SF) by direct compression method. Obtained tablets were characterized...