Data suggest inadequacy of common statistical techniques for reporting outcomes in clinical trials. The Fragility Index can measure how many events the statistical significance hinges on, and may facilitate better interpretation of trial results. This study aimed to assess the Fragility Index in pediatric randomized controlled trials (RCTs) with statistically significant findings published in h...

conclusions in middle-aged subjects with psc, we found a high rate of non-vertebral fractures and a moderately decreased bmd in lumbar spine and hip. fragility fractures had an impact on physical and mental aspects of hrqol. results in 32% of patients, bmd measured in the hip or spine was below 1.0 standard deviation. a history of fragility fractures (distal forearm and ribs) was reported in si...

The osmotic fragility of erythrocytes is known to undergo alterations when whole blood is incubated under aseptic conditions for 24 hours. The osmotic fragility of spherocytes increases considerably ( 1 ). Normal erythrocytes undergo a slight increase in fragility (2) and by contrast the osmotic fragility of leptocytes and certain other erythrocytes (3) is decreased. The sequence of events asso...

Brittle Nails Syndrome is characterized by fragility of the nail plate, affecting 27% of women. We evaluated dermatology patients in a cross-sectional study about perception of nail fragility. One hundred and thirty eight women were included, with median age of 36.5 years. Nail examination showed changes in 57% and 49% reported nail fragility. The first three fingernails were the most affected....

The aim of the paper is to present the Delta 20 Fragility-Rings plot and its use for robustness-fragility analysis of proportional integral (PI) and proportional integral derivative (PID) controllers. Using the Delta 20 Fragility Index and the Nyquist plot it shows the areas on the L(jω) plane corresponding to robustness-fragile, robustness-non-fragile and robustnessresilient controllers provid...

A multi-dimensional definition of fragility is developed considering multiple variables such as floor acceleration and interstory drifts. The limit states which have uncertainties are defined as random variables in the calculation of fragility. A random description of the limit state has been adopted to calculate fragility and different cases have been considered. A case study of a Hospital loc...

In the literature there is no clear evidence of a relationship between thyropathies and fragility fractures. The aim of our study is to define the prevalence of thyroid disease in a study sample made up of subjects with fragility fractures and from the same geographical area. We retrospectively studied the "hospital discharge records" (HDR) in the Apulian Database for the period 2008-2013 in or...

This paper presents the formulation of a time-dependent seismic fragility format for bridges, as well as new insights into the potential effects of aging and deterioration on seismic vulnerability traditionally neglected in fragility modeling, including joint impacts of multiple component deterioration not investigated to date. The study evaluates the impact of lifetime exposure to chlorides fr...

This paper presents a statistical analysis of structural fragility curves. Both empirical and analytical fragility curves are considered. The empirical fragility curves are developed utilizing bridge damage data obtained from the 1995 Hyogo-ken Nanbu (Kobe) earthquake. The analytical fragility curves are constructed on the basis of the nonlinear dynamic analysis. Two-parameter lognormal distrib...