نتایج جستجو برای: founder
تعداد نتایج: 7578 فیلتر نتایج به سال:
The importance of founder events in promoting evolutionary changes on islands has been a subject of long-running controversy. Resolution of this debate has been hindered by a lack of empirical evidence from naturally founded island populations. Here we undertake a genetic analysis of a series of historically documented, natural colonization events by the silvereye species-complex (Zosterops lat...
Drawing on impression management and social exchange theory, we examine the use of positively biased forecasts by (non-)founder-CEOs as an tactic vis-à-vis their existing investors. Contrary to non-founder counterparts, founder-CEOs identify more with venture they founded and, therefore, experience greater instrumental affective concerns about long-term relationship Consequently, hypothesize th...
The extant literature on family-controlled firms in the U.S. presents a mixed picture on how family control affects opacity and value creation. In this study, we show that the mixed results could result from the differences among family firms with regard to the presence of founders and the extent of decision rights held by them. Specifically, we find that family firms in which founders are pres...
In emerging markets, the deviation between the ultimate controlling shareholders’ voting rights and their cash flow rights (hereafter “DVC”) in the listed firms is quite prevalent. DVC could be introduced due to the ultimate controlling shareholders’ opportunistic incentives, as well as by their incentives to improve firm efficiency. This study uses 229 listed firms ultimately controlled by ind...
Dense genotype data can be used to detect chromosome fragments inherited from a common ancestor in apparently unrelated individuals. A disease-causing mutation inherited from a common founder may thus be detected by searching for a common haplotype signature in a sample population of patients. We present here FounderTracker, a computational method for the genome-wide detection of founder mutati...
In this paper we study some causes and consequences of founder-CEO replacements among a sample of 4,172 Danish startups created by single founders in 1999 and 2000. In contrast to the extant literature on VC-financed firms, replacements among firms in our sample are more likely among the worstand best-performing firms, and replacement is not unambiguously associated with better subsequent perfo...
Identifying founder mutations in BRCA1 and BRCA2 in specific populations constitute a valuable opportunity for genetic screening. Several studies from different populations have reported recurrent and/or founder mutations representing a relevant proportion of BRCA mutation carriers. In Latin America, only few founder mutations have been described. We screened 453 Chilean patients with hereditar...
The Mediterranean basin has been the theater of migration crossroads followed by settlement of several societies and cultures in prehistoric and historical times, with important consequences on genetic and genomic determinisms. Here, we present the Mediterranean Founder Mutation Database (MFMD), established to offer web-based access to founder mutation information in the Mediterranean populatio...
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