Formulated products represent a particular class of complex chemical products, and their design is typically based on experience extensive experimentation. Although still at an early stage, despite that potential not fully accessed used by the industry, computer-aided (CAD) methods tools offer many possibilities in formulated products. The CAD methodology computerized models enables formulation...

succinate) was the first triptan medication to target the nerves and blood vessels believed to trigger a total migraine (including throbbing pain, nausea, and sensitivity to light and sound, with or without aura). The first triptan to receive Food and Drug Administration (FDA) approval for the acute treatment of migraines in adults, IMITREX has treated more than 750 million migraines in the pas...

We present a consistent formulation of quantum game theory that accommodates all possible strategies in Hilbert space. The physical content of the quantum strategy is revealed as a family of classical games representing altruistic game play supplemented by quantum interferences. Crucial role of the entanglement in quantum strategy is illustrated by an example of quantum game representing the Be...

We use a “weakly formulated” Sylvester equation H1/2TM−1/2 −H−1/2TM1/2 = F to obtain new bounds for the rotation of spectral subspaces of a nonnegative selfadjoint operator in a Hilbert space. Our bound extends the known results of Davis and Kahan. Another application is a bound for the square root of a positive selfadjoint operator which extends the known rule: “The relative error in the squar...

high mortality and labor costs are associated with first-feeding sturgeon culture, particularly during the period of dietary transition from live to formulated feed. therefore we investigated the effects of various feeding treatments on the survival and growth of the persian sturgeon ( acipenser persicus ) larvae during a 20-day culture period. three replicate groups (250 fish/replicate) of fir...

The study aimed to combine two antidiabetic agents with different mechanisms of action, namely, metformin HCl and rosiglitazone maleate, in a tablet to improve glycemic control in patients with type II diabetes. The preformulation study started with development and validation of an HPLC method for the determination of both drugs in the mixture. The results of visual inspection, TLC, DSC, and FT...

Robert (“Bob”) Zwanzig died on May 15 this year at the age of 86. He had been a member of the National Academy of Sciences since 1972. He is survived by Frances, his wife of 60 years, a daughter, Elizabeth Bennett, and a son, Carl. Frances writes that Bob “was a baker of bread and of made-from-scratch pizza, a maker of dry martinis and hearty soups, an ice dancer, and a walker along the Chesape...