Introduction Follicular thyroid cancer, similar to follicular adenoma, usually takes the form of a round, encapsulated tumour. Cytological examination does not allow a firm diagnosis of follicular thyroid cancer to be made. Follicular thyroid cancer can be diagnosed by histopathological examination only after demonstrating the infiltration of the capsule by the tumour and/or vessel invasion. Th...

Thyroid cancer accounts for approximately 1% of all human cancers. Follicular carcinoma thyroid (FCT) is the second most common thyroid cancer after papillary carcinoma. Follicular carcinoma thyroid accounts for 10-15% of clinically evident thyroid malignancies. Follicular carcinoma thyroid commonly metastasize to lung and bone. Intracranial metastasis occurs in about only 1%. Follicular carcin...

Medical records of 228 patients who had undergone thyroid surgery were studied. There were 179 females and 49 males with mean age of 33-8 years. Pre-op. diagnosis was cold nodule in 4. 4 %. Pathology diagnosis was simple goiter in 54%, adenoma in 23%, thyroid cancer in 15% and colloid cyst in 5.3% of the patients. Among carcinomas 68% were papillary, 29% follicular and 3% medullary. There were1...

Familial follicular cell-derived well-differentiated thyroid cancer, papillary (PTC), and follicular thyroid carcinomas (FTC), accounts for 95% of thyroid malignancies. The majority of are sporadic, and at least 5% of these patients will have familial disease. Familial thyroid syndromes are classified into familial medullary thyroid carcinoma (FMTC), derived from calcitonin-producing C cells, a...

Nobody wants to get cancer, but if you have to, thyroid cancer is a good one to get because of its excellent prognosis. Still, there is plenty of room for improvement in the current approaches to the diagnosis and therapy of this disease. Thyroid cancer is the most common endocrine malignancy. The American Cancer Society estimates 37 000 new cases of thyroid cancer were diagnosed in the US in 2...

Thyroid cancer is the most common malignancy in endocrine system, composed of four major types; papillary thyroid carcinoma, follicular thyroid carcinoma, anaplastic thyroid carcinoma, and medullary thyroid carcinoma. The incidence of thyroid cancer, especially differentiated thyroid cancer, is increasing in developed countries. Growing body of studies on molecular pathogenesis in thyroid cance...

Thyroid cancer is the most common endocrine malignancy. However, more than 90% of thyroid nodules are benign. It remains unclear whether thyroid carcinoma arises from preexisting benign nodules. Metabolomics can provide valuable and comprehensive information about low molecular weight compounds present in living systems and further our understanding of the biology regulating pathological proces...

INTRODUCTION Akt activation is involved in the pathogenesis of inherited thyroid cancer in Cowden's syndrome and in sporadic thyroid cancers. In cell culture, Akt regulates thyroid cell growth and survival; but recent data suggest that Akt also regulates cell motility in non-thyroid cell lines. We therefore sought to evaluate the role of Akt in thyroid cancer progression. METHODS We evaluated...

The inability to distinguish microinvasive follicular thyroid cancer from benign follicular tumors preoperatively presents an important surgical dilemma. We examined 44 follicular tumors and found telomerase activity in all 11 follicular carcinomas and in 8 of 33 benign follicular tumors. It was undetectable in 22 normal thyroid tissues adjacent to the tumors. Telomerase activity may thus provi...

Follicular thyroid cancer rarely manifests itself as a distant metastatic lesion. We report a case of an otherwise asymptomatic 58-year-old woman with follicular thyroid cancer who initially presented with a soft tissue mass on the right scapular region. An incisional biopsy specimen of soft tissue metastasis showed thyroid follicular neoplasm. Upon this diagnosis, the thyroid gland was re-eval...