Two full-length cDNA clones (2.2 kilobases) encoding a newly recognized form of mammalian flavincontaining monooxygenase (FMO) have been isolated from independent libraries constructed with mRNA from different rabbits. The cDNAs encode a polypeptide of 533 amino acids which contains two putative pyrophosphate binding domains and a hydrophobic carboxyl terminus characteristic of FMOs. This seque...

Our previous studies have shown the therapeutic efficacy and underlying mechanisms of Peony-Glycyrrhiza Decoction (PGD), an herbal preparation, in treating antipsychotic-induced hyperprolactinemia in cultured cells, animal models, and human subjects. In the present study, we further evaluated pharmacokinetic interactions of PGD with clozapine (CLZ) in human liver microsomes (HLM), recombinantly...

The potential roles of human hepatic and renal flavin-containing monooxygenases (FMOs) in the metabolism of the cysteine S-conjugates S-allyl cysteine (SAC) and S-(1,2-dichlorovinyl)-L-cysteine (DCVC) were investigated. Incubations of human cDNA-expressed FMO1, FMO3, FMO4, and FMO5 with SAC resulted in detection of SAC sulfoxide, with FMO3 exhibiting approximately 3-, 4-, and 10-fold higher act...

Many applications of machine learning involve structured outputs with large domains, where learning of a structured predictor is prohibitive due to repetitive calls to an expensive inference oracle. In this work, we show that by decomposing training of a Structural Support Vector Machine (SVM) into a series of multiclass SVM problems connected through messages, one can replace an expensive stru...

We present a spectroscopic survey of galaxies in the COSMOS field using the Fiber Multi-Object Spectrograph (FMOS), a near-infrared instrument on the Subaru Telescope. Our survey is specifically designed to detect the Hα emission line that falls within the H-band (1.6-1.8 μm) spectroscopic window from star-forming galaxies with 1.4 < z < 1.7 and Mstellar & 10 10 M⊙. With the high multiplex capa...

One of the main factors limiting the yield and productivity of irrigated rice in the Sahel of West Africa is the high cost of fertilizers and inefficient use of nutrients in the cropping systems. A two-year experiment was conducted over four consecutive seasons at Ndiaye (16°11’N, 16°15’W) and Fanaye (16°32’N, 15°11’W) along the Senegal River Valley to investigate alternative fertilizer managem...

In this manuscript, we will illustrate a new idea for narrowing energy gaps between frontier molecular orbitals (FMOs) by selectively perturbing the levels of highest occupied (HOMOs) and/or lowest unoccupied (LUMOs). Initially, basic concept isolated FMOs is explained employing pentaazaphenalene (5AP) derivatives. It was found that electronic structures LUMO 5AP can be preserved even when inco...