introduction: foot-and-mouth disease (fmd) is a highly contagious and economically devastating viral disease of livestock that is categorized in list a of animal diseases by the world organisation for animal health (oie). vaccination is effective against fmd and the vaccine production centers largely use the industrial ultra-filtration and chromatography in order to remove the cellular proteins...

It is about 50 years that FMD affected the ruminants of Isfahan. Last outbreaks of FMD were happened at 2005 even vaccinated animals, so in current work using RT-PCR, sequencing and regression "r" values, the isolated strains in Isfahan were identified. The aim of this study was molecular epidemiology of FMDV in Isfahan province as the central part of Iran in 2006-2009. According to the result ...

Foot-and-mouth disease is an important viral disease of cloven-hoofed animals. Inactivated whole particle virus vaccines are still widely used in prophylactic vaccination campaigns. The choice of adjuvant is a very important factor in enhancing immune responses and the efficacy of inactivated vaccines. Montanide ISA 61 VG is a new ready-to-use mineral oil-based adjuvant developed by SEPPIC Inc....

foot and mouth disease (fmd) is the most contagious disease of cloven-hoofed animals, causingsignificant economical losses in livestock animals. in this study fmd virus type a87/irn was cultured andmultiplied on bhk21 cells. the fmd virus was titrated by the tissue culture infection dose50 method(tcid50 /ml), the virus titration was 107.5.. the fmd virus samples were irradiated and inactivated ...

Twelve apparently healthy and recently parturiated Murrah buffaloes, vaccinated with Foot-and-mouth disease (FMD) + Haemorrhagic septicaemia (HS) combined vaccine at an organized farm along their newborn calves were inducted for detection of antibodies in serum colostrum against FMD virus (FMDV) serotypes O, A Asia-1, Pasteurella multocida using enzyme linked immunosorbent assay. The born to da...

The Global Foot-and-mouth disease (FMD) Research Alliance periodically reviews the state of FMD research to assess progress and to identify new priorities. In this supplement we provide an update of global FMD research, comprising (i) this overview paper, which includes background information with key findings, and papers covering (ii) epidemiology, wildlife and economics, (iii) vaccines, (iv) ...

Aim: The present work was established in order to investigate the effect of ultra-corn administration on the immune response of vaccinated calves with FMD bivalent oil vaccine. Material and Methods: Forty calves; at a private farm in EL-Fayoum Governorate (Locality A); were divided into 4 groups nd rd th where the first group was vaccinated with the locally produced FMD bivalent oil vaccine alo...

foot-and-mouth disease is an important viral disease of cloven-hoofed animals. inactivated whole particle virus vaccines are still widely used in prophylactic vaccination campaigns. the choice of adjuvant is a very important factor in enhancing immune responses and the efficacy of inactivated vaccines. montanide isa 61 vg is a new ready-to-use mineral oil-based adjuvant developed by seppic inc....

Foot-and-mouth disease virus (FMDV) causes a highly contagious infection in cloven-hoofed animals. The format of FMD virus-like particles (VLP) as a non-replicating particulate vaccine candidate is a promising alternative to conventional inactivated FMDV vaccines. In this study, we explored a prokaryotic system to express and assemble the FMD VLP and validated the potential of VLP as an FMDV va...

The choice of the most appropriate strains of foot and mouth disease (FMD) virus vaccines to use in FMD control programmes and to store in vaccine antigen reserves is based on the matching of representative field isolates from outbreaks around the world to available vaccine strains. However, those involved in FMD control at a national level do not always give this work a high priority, while in...