Neuroleptic malignant syndrome is an uncommon but dangerous complication of antipsychotic drugs, characterized by clinical symptoms that include hyperthermia, severe muscle rigidity, autonomic dysfunction, and altered mental state. Serum creatine kinase (CK) elevation occurs in over 90% of cases. Many diagnostic criteria sets for neuroleptic malignant syndrome have been proposed, all of which i...

OBJECTIVE The pathophysiology of neuroleptic malignant syndrome is mainly explained by a central hypodopaminergic state. The familial occurrence of neuroleptic malignant syndrome suggests the involvement of a genetic mechanism in the predisposition to the syndrome. Therefore, the authors examined the association between the TaqI A polymorphism of the dopamine D(2) receptor gene (DRD(2)), which ...

this paper reports five cases of neuroleptic malignant syndrome, admitted to shahid navab safavi psychiatric center during a period of six months. the onset and course of syndrome, types of drugs prescribed, and the variety of symptoms, were studied. results showed that early diagnosis of the syndrome, cessation of neuroleptic drugs, and classical treatment were efective in saving the lives of ...

BACKGROUND: The neuroleptic malignant syndrome is a rare but serious condition mainly associated with antipsychotic medication. There are controversies as to whether "classical" forms of neuroleptic malignant syndrome can occur in patients given atypical antipsychotics. The serotonin syndrome is caused by drug-induced excess of intrasynaptic 5-hydroxytryptamine. The possible relationship betwee...

This study, a retrospective chart review of 82 consecutive male inpatients, assessed the spectrum and prevalence of neuroleptic malignant syndrome. The prevalence of diagnosed neuroleptic malignant syndrome (2.4%) was greater than that generally reported. Eight additional patients manifested symptoms that abated without cessation of neuroleptic treatment. This suggests that neuroleptic malignan...

A 55-year-old woman with a history of bipolar affective disorder developed hyperpyrexia, rigidity and depressed consciousness (neuroleptic malignant syndrome) after commencing neuroleptic therapy. On regaining consciousness, she was mute and had signs suggesting pancerebellar involvement. Hyperpyrexia, which is a cardinal feature of neuroleptic malignant syndrome, may have caused cerebellar dam...

ajp.psychiatryonline.org neuroleptic malignant syndrome (1, 2). Other investigators have reported typical neuroleptic malignant syndrome features from treatment with atypical antipsychotics (4). Although our patient presented with neck stiffness, no rigidity was found, and no fever was initially noted. Additionally, he did not manifest a number of symptoms associated with neuroleptic malignant ...