Background: As bremsstrahlung photon beam fluence is important parameter to be known in a photonuclear reaction experiment as the number of produced particle is strongly depends on photon fluence. Materials and Methods: Photon production yield from different thickness of aluminum target has been estimated using artificial neural network (ANN) model. Target thickness and incoming electr...

BACKGROUND AND OBJECTIVES Molecular oxygen in the tissue to be treated by photodynamic therapy (PDT) is critical for photodynamic cell killing. The fluence rate of PDT light delivery has been identified as an important modulator of tissue oxygenation and treatment outcome. This article provides supporting evidence for the role of fluence rate in PDT and discusses the underlying mechanisms. ST...

Photoacoustic imaging (PAI) is a non-invasive and non-ionizing imaging modality that combines the absorption contrast of light with ultrasound resolution. Laser is used to deposit optical energy into a target (i.e., optical fluence). Consequently, the target temperature rises, and then thermal expansion occurs that leads to generating a PA signal. In general, most image reconstruction algorithm...

Laser irradiation parameters, especially the laser fluence and the number of pulses are very important factors affecting microstructures formation and improvement of the surface characteristics in different medical, electronic and the other industrial applications. Information about the fluence domain and the number of pulses for the formation of the structures is very important and determines ...

The response of human glioma spheroids to 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) is investigated. A two-photon fluorescence microscopy technique is used to show that human glioma cells readily convert ALA to protoporphyrin IX throughout the entire spheroid volume. The central finding of this study is that the response of human glioma spheroids to ALA-mediated PDT depend...

Introduction International Commission on Radiological Protection (ICRP) has provided a comprehensive discussion on threshold dose for radiation-induced cataract in ICRP publication 116. Accordingly, various parts of the eye lens have different radio-sensitivities. Recently, some studies have been performed to develop a realistic eye model with the aim of providing accurate estimation of fluence...

The rate of light delivery (fluence rate) plays a critical role in photodynamic therapy (PDT) through its control of tumor oxygenation. This study tests the hypothesis that fluence rate also influences the inflammatory responses associated with PDT. PDT regimens of two different fluences (48 and 128 J/cm(2)) were designed for the Colo 26 murine tumor that either conserved or depleted tissue oxy...

BACKGROUND AND OBJECTIVES Previous studies with PhotoDynamic Therapy (PDT) in bladder and bronchi have shown that due to scattering and reflection, the actually delivered fluence rate on the surface in a hollow organ can be significantly higher than expected. In this pilot study, we investigated the differences between the primary calculated and the actual measured fluence rate during PDT of Ba...

We have modified the existing convolution method of the Monte Carlo simulation for finite photon beams with both translational and rotational invariance. The modified convolution method was applied to simulate the optical fluence distribution in tissue in dark-field confocal photoacoustic microscopy. We studied the influence of the size of the dark field and the illumination incident angle on t...