All-trans retinoic acid (ATRA), as an active metabolite of vitamin A, has been shown to affect immune cells. This study was performed to evaluate the effect of ATRA on viability, proliferation, activation and lineage-specific transcription factors of CD4+ T cells. CD4+ T cells were separated from heparinized blood of healthy donors and were cultured in conditions, some with, some without ATRA. ...

background: ovarian cancer is the fifth leading cause of death from malignancy in women. cd4 +cd25+foxp3+ regulatory t (treg) cells are a subset of t lymphocytes with great inhibitory impact on immune response. objectives: to investigate the percentage of cd4 +cd25+foxp3+ regulatory t cells in the peripheral blood of the iranian patients with epithelial ovarian cancer compared to healthy women ...

OBJECTIVES Both chronic kidney disease (CKD) and hemodialysis (HD) are reported to elevate oxidative stress. Available evidence for oxidative stress is indirect measurement of oxidative stress as accumulation of byproducts by reactive oxygen species (ROS). We aimed to examine the effect of CKD and HD on ROS levels in circulating leukocytes and to compare those with conventional oxidative stress...

Ultra early posttransplantation lymphoproliferative disorder (PTLD) is a rare and fatal complication after hematopoietic stem cell transplantation (HSCT). Here we report, by lymph node (LN) flowcytometry, that we early recognized ultra early PTLD after an HLA-matched sibling allo-HSCT followed by a successful treatment with anti-CD20 antibody (rituximab) in a patient in progress disease for ang...

there exists compelling evidence that toll-like receptor 3 (tlr3) agonists can directly affect human cancer cells. the aim of this study was to investigate anti-cancer effects of tlr3 agonist in human breast cell line. we assessed potential effects of poly (a:u) on human breast cell line (mda-mb-231)  on a dose-response and time-course  basis. human breast cell line  mda-mb-231  was treated wit...

Aim Lipoaspirate, a wasted by product from liposuction procedure recently has been shown to contain abundant mesenchymal stem cells (MSCs). MSCs have been studied in many research areas to regenerate many cell lineages including, myogenic, cardiomyogenic, and angiogenic lineages. The large quantity of MSCs in lipoaspirate, makes it an attractive source for stem cells used in research and clinic...

BACKGROUND Recent publications about differentiation of stem cells to germ cells have motivated researchers to make new approaches to infertility. In vitro production of germ cells improves understanding differentiation process of male and female germ cells. Due to the problem of using embryonic stem cells (ESC), it's necessary the mentioned cells be replaced with some adult multi-potent stem c...