an oral sustained-release floating tablet formulation of metformin hcl was designed and developed. effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and hpmc-peo polymer combination, respectively. tablet composition was optimized by response surface methodology (rsm). seventeen (17) trial formulations were analyzed according to box-behnken desi...

Abstract This paper aims to find out the most vulnerable position and suitable clearance ratio of floating sleeve between inside outside tricone bit. In this paper, mechanical analysis model drill bit is established get simulated working condition tri-cone bit, then stress bearing simulated. Finally, multi-factor variable orthogonal test method used optimize sleeve. The results show that simula...

i. Low overhead automated and precise detection of concurrency bugs at scale. ii. Using low overhead bug detection tools to guide speculative program transformations for performance. iii. Techniques to reduce the concurrency required to reproduce a bug using partial program restart/replay. iv. Techniques to provide reproducible execution of floating point programs. v. Techniques for tuning the ...

This paper proposes a novel approach for an optimal multi-objective optimization for VLSI implementation of Artificial Neural Network (ANN) which is area-power-speed efficient and has high degree of accuracy and dynamic range. A VLSI implementation of feed forward neural network in floating point arithmetic IEEE-754 single precision 32 bit format is presented that makes the use of digital weigh...

one of the main concerns of the mining industry is to determine ultimate pit limits. final pit is a collection of blocks, which can be removed with maximum profit while following restrictions on the slope of the mine’s walls. the size, location and final shape of an open-pit are very important in designing the location of waste dumps, stockpiles, processing plants, access roads and other surfac...

A new generation method to implement CMOS floating resistors is presented. The generation method depends on the linearization of the differential current of two matched NMOS transistors in two alternative configurations. The CMOS floating resistors implemented are based on using MOS transistors operating in the saturation region with their sources connected to their substrates. New CMOS floatin...

One of the main concerns of the mining industry is to determine ultimate pit limits. Final pit is a collection of blocks, which can be removed with maximum profit while following restrictions on the slope of the mine’s walls. The size, location and final shape of an open-pit are very important in designing the location of waste dumps, stockpiles, processing plants, access roads and other surfac...

for prolonging the time that drug remains in stomach, new methods used as floating drug delivery systems, that available in various forms such as floating tablets. these systems enhance drug absorption and decrease plasma concentration fluctuations. iron deficiency and its inadequate absorption in diet are of community health problems. for prolonging the time that drug remains in stomach, new m...