A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-MS/MS) method for determination of gefitinib in rat plasma using one-step protein precipitation was developed. After addition of estazolam as internal standard (IS), protein precipitation by acetonitrile was used as sample preparation. Chromatographic separation was achieved on an SB-C18 (2.1 mm × 50 mm, 3.5 μm) col...

Morphological variation in Ephedra (Gnetales) is limited and confusing from an evolutionary perspective, with parallelisms and intraspecific variation. However, recent analyses of molecular data provide a phylogenetic framework for investigations of morphological traits, albeit with few informative characters in the investigated gene regions. We document morphological, anatomical and histologic...

The World Jurist Association’s Conference on International Arbitration and ADR – the Impact on the Rule of Law was held April 5 – 7, 2011 in Grand Baie, Mauritius. This Conference brought together 150 distinguished delegates and speakers from 20 countries, representing every region of the world. Our Host Committee was chaired by Honorable YKJ Yeung Sik Yuen, GOSK, Chief Justice of the Supreme C...

This paper investigates the (conditional) quasi-likelihood ratio test for the threshold in MA models. Under the hypothesis of no threshold, it is shown that the test statistic converges weakly to a function of the centred Gaussian process. Under local alternatives, it is shown that this test has nontrivial asymptotic power. The results are based on a new weak convergence of a linear marked empi...