conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...

background hepatic fibrosis is an inclusion indicator for treatment and a major independent predictor of treatment response in patients with chronic hepatitis c. liver biopsy, considered as the “gold standard” for evaluating liver fibrosis, has carried some drawbacks. currently used noninvasive predictors of fibrosis are considered less accurate than liver biopsy. objectives our aim was to asse...

background: cystic fibrosis (cf) is a common autosomal recessive disorder that affects many body systems and is produced by mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene. cf is also the most frequently inherited disorder in the west. the aim of this study was to detect the mutations in the cftr gene in two iranian families with cf. methods: after dna extractio...

antifibrotic therapies should preferentially be targeted to the activated hepatic mesenchymal cells. those cells resemble wound healing myofibroblasts and synthesize an excess of extracellular matrix (ecm) proteins. they derive from quiescent hepatic stellate cells (hsc) and portal/perivascular (myo-) fibroblasts (mf). whereas various agents have been shown to inhibit hsc/mf proliferation and c...

â  â  b ackground cystic fibrosis (cf) is an autosomal recessive disease caused by a cf trans-membrane regulator (cftr) defect. its prevalence is 1:2500 in caucasians, 1:15300 among african americans and is rare in southâ­east asia. the present study aims to review demographic data, clinical manifestations and laboratory findings of iranian children diagnosed with cf who referred to a childrenâ...

context cystic fibrosis (cf) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the caucasian population. as the median survival has increased related to early multidisciplinary intervention, other manifestations of cf have emergedespecially for the broad spectrum of hepatobiliary involvement. the present study reviews the existing literature on liv...

retroperitoneal fibrosis (rpf) is a rare condition with an unclear etiology, presenting with the development of aberrant chronic nonspecific fibroinflammatory tissue in the retroperitoneal space, which can result in entrapment and obstruction of the retroperitoneal structures. rpf is a subtype of chronic periaortitis, and can be divided into two types: primary (or idiopathic) and secondary. rpf...