Abstract Background Delta beta (δβ) thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF). Homozygous patients of this disorder, unlike β-thalassemia, show mild anemia. Only few cases of δβ-thalassemia have been reported from India in the available indexed English literature. Case presentation A four-year old male child was evaluated for recent-onset...

background: when fetal red cells enter the maternal circulation from placenta, an event would be happened that is described as feto-maternal hemorrhage (fmh). this life-threatening condition could be detected by using rbc antigens (surface antigens and intracellular antigens). therefore, the measurement of fetal rbc in an artificial model would be useful to calculate fmh and consequently the do...

the effects of electromagnetic fields (emfs) radiation at the frequency of 940 mhz on the structure and function of human adult and fetal hemoglobin (hba and hbf) were studied. after extraction and purification of hba and hbf, the oxygen absorption values for exposed and unexposed hba and hbf to emf were compared. the slope of oxygen absorption curve for exposed hba was increased while that for...

The fetal hemoglobin in the affected members of three Greek families with the hereditary persistence of fetal hemoglobin has only gamma-chains of the type with alanine in position 136. Although certain Negro families had been considered to have only this type of gamma-chains in their fetal hemoglobin, further studies required that they be reclassified. Consequently, the Greek cases are the sole...

Interferons have the ability to enhance or diminish the expression of specific genes and have been shown to affect the proliferation of certain cells. Here. the effect of ‘yinterferon on fetal hemoglobin synthesis by purified cord blood. fetal liver. and adult bone marrow erythroid progenitors was studied with a radioligand assay to measure hemoglobin production by BFU-E-derived erythroblasts. ...

background: β-thalassemia considers worldwide public health disorders. novel fetal hemoglobin inducer agents such as thalidomide and sodium butyrate have been attended for ameliorating clinical complications of such disorders. material and methods: we used thalidomide and sodium butyrate for increasing the level of fetal hemoglobin in erythroid progenitors. briefly, after isolation of cd133+ st...

Homozygous sickle cell disease in the eastern province of Saudi Arabia is clinically mild. Circulating fetal hemoglobin levels of 16.0 +/- 7.4% were found in these anemic patients, but only 1.09 +/- 0.97% in their sickle trait parents. To determine whether these sickle cell anemia patients inherit an increased capacity to synthesize fetal hemoglobin, a radioimmunoassay of fetal and adult hemogl...

A 4-yr-old boy was studied who placed to the left of the curve from showed typical findings of juvenile normal adult blood; the hemoglobin chronic myelogenous leukemia, inA2 level and the erythrocyte I antigen cluding massive hepatosplenomegaly, titer were reduced; and a structural thrombocytopenia, low leukocyte alkaanalysis of the ‘i-chain of the fetal line phosphatase, and absence of a hemog...

What causes the gradual decrease of fetal hemoglobin in the normal maturing infant, or the persistence of fetal hemoglobin in the blood of adults with certain congenital anemias, especially thalassemia, is not known. The production of fetal hemoglobin is evidently determined by genes nonallelic with those regulating adult hemoglobin formation (1). The fact that all red cells can be sickled in s...