نتایج جستجو برای: female life span

تعداد نتایج: 1023060  

Journal: :Fly 2011
Gregory F Oxenkrug Valeria Navrotskaya Lyudmila Voroboyva Paul Summergrad

Upregulation of kynurenine (KYN) formation from tryptophan (TRY) was associated with aging in animal and human studies. TRY - KYN metabolism is affected by the activities of TRY 2,3-dioxygenase 2 (TDO) and ATP-binding cassette (ABC) transporter regulating TRY access to intracellular TDO. We studied the effects of TDO inhibitor, alpha-methyl tryptophan (aMT), and ABC transported inhibitor, 5-met...

2015
Valeria Benedusi Elisa Martini Marinos Kallikourdis Alessandro Villa Clara Meda Adriana Maggi

This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNFα, IL-1β, MCP-1, MIP-2 and IL-6 mRNA con...

Journal: :Japanese Journal of Health and Human Ecology 1995

Journal: :Journal of biological rhythms 2002
Malgorzata Oklejewicz Serge Daan

The single-gene mutation tau in the Syrian hamster shortens the circadian period by about 20% in the homozygous mutant and simultaneously increases the mass-specific metabolic rate by about 20%. Both effects might be expected to lead to a change in longevity. To test such expectations, the life span of male and female hamsters from three genotypes (wild-type, heterozygous, and homozygous tau mu...

Journal: :The journals of gerontology. Series A, Biological sciences and medical sciences 2014
Antonello Lorenzini Adam B Salmon Chad Lerner Claudio Torres Yuji Ikeno Susan Motch Roger McCarter Christian Sell

Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that reducing levels of IGF-1 may also increase life span. However, the data are conflicting and complicated by the physiology of the mammalian neuroendocrine system. We have performed life-span analysis on mice homozygous for an insertion in t...

2011
Vladimir N. Anisimov Lev M. Berstein Irina G. Popovich Mark A. Zabezhinski Peter A. Egormin Tatiana S. Piskunova Anna V. Semenchenko Margarita L. Tyndyk Maria N. Yurova Irina G. Kovalenko Tatiana E. Poroshina

Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer in mice, although its effects vary, depending on mice strain and gender. Here we showed that chronic treatment of female outbred SHR mice with metformin started at the age of 3, 9 or 15 months d...

Journal: :The journals of gerontology. Series A, Biological sciences and medical sciences 2016
Martin I Lind Martyna K Zwoinska Sara Meurling Hanne Carlsson Alexei A Maklakov

Rapamycin inhibits the nutrient-sensing TOR pathway and extends life span in a wide range of organisms. Although life-span extension usually differs between the sexes, the reason for this is poorly understood. Because TOR influences growth, rapamycin likely affects life-history traits such as growth and reproduction. Sexes have different life-history strategies, and theory predicts that they wi...

Journal: :Human biology 2004
Anatoly T Teriokhin Elena V Budilova Frederic Thomas Jean-Francois Guegan

In all human populations mean life span of women generally exceeds that of men, but the extent of this sexual dimorphism varies across different regions of the world. Our purpose here is to study, using global demographic and environmental data, the general tendency of this variation and local deviations from it. We used data on male and female life history traits and environmental conditions f...

Journal: :Evolution; international journal of organic evolution 2014
David Berger Elena C Berg William Widegren Göran Arnqvist Alexei A Maklakov

Intralocus sexual conflict (IaSC) is pervasive because males and females experience differences in selection but share much of the same genome. Traits with integrated genetic architecture should be reservoirs of sexually antagonistic genetic variation for fitness, but explorations of multivariate IaSC are scarce. Previously, we showed that upward artificial selection on male life span decreased...

Journal: :The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2001

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