The Docile strain of lymphocytic choriomeningitis virus (LCMV) induces anemia in a number of inbred strains of mice, including C3HeB/FeJ and CBA/Ht animals. A difference in the kinetics of anemia and in compensatory reticulocytosis suggested that impaired erythropoiesis was the major pathogenic mechanism involved in CBA/Ht mice, but not in C3HeB/FeJ mice. In both mouse strains an antierythrocyt...

The modifying role of age, sex, and strain upon the incidence, multiplicity, and spectrum of tumors induced by ethylnitrosourea, a short-acting carcinogen, has been studied. The first-generation (F,) hybrids of C57BL/6J X C3HeB/FeJ and C3HeB/FeJ X A/J mice of both sexes were given single i.p. injections (60 or 120 Mg/g) of ethylnitrosourea at 1, 15, or 42 days of age. Experimental animals were ...

The modifying role of age, sex, and strain upon the incidence, multiplicity, and spectrum of tumors induced by ethylnitrosourea, a short-acting carcinogen, has been studied. The first-generation (F,) hybrids of C57BL/6J X C3HeB/FeJ and C3HeB/FeJ X A/J mice of both sexes were given single i.p. injections (60 or 120 Mg/g) of ethylnitrosourea at 1, 15, or 42 days of age. Experimental animals were ...

The modifying roles of age, sex, and strain of mice on the incidence, multiplicity, and spectrum of tumors induced by benzo(a)pyrene have been investigated. The first-generation (F1) hybrids of C57BL/6J X C3HeB/FeJ and C3HEB/Fej X A/J mice of both sexes were given single i.p. injections (75 or 150 mug/g) of benzo(a)pyrene at 1, 15, or 42 days of age. Experimental animals were allowed to live th...

Inbred mouse strains vary in their response to bitter-tasting compounds as assessed by 48 h preference tests. These differences are generally assumed to result from altered gustatory function, although such long-term tests could easily reflect additional factors. We developed a brief-access taste test and tested the responses of two inbred strains, as well as C3. SW congenic mice, to the bitter...

The purpose of this study was to determine whether endotoxin decreased hepatic glucocorticoid binding by the action of mediator(s). Steroid binding in liver cytosol, plasma glucose levels, and plasma corticosterone levels were assayed in C3HeB/FeJ LPS normoresponsive and C3H/HeJ LPS hyporesponsive mice. In C3HeB/FeJ mice, endotoxin significantly depressed the maximum number of steroid binding s...

Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel tuberculosis drugs and drug regimens. Pulmonary disease in humans is characterized by a number of heterogeneous lesion types that reflect differences in cellular composition and organization, extent of encapsulation, and degree of caseous necrosis. ...

The response of lymphoreticular tissues to a single i.p. injection of benzo(a)pyrene was studied in the first generation of C57BL/6J X C3HeB/FeJ F1 and C3HeB/FeJ X A/J F1 mice. Groups of 1-, 15-, and 42-day-old animals of both sexes received 75 or 150 mug of the carcinogen per g body weight. After a period of approximately 90 weeks, a high incidence (up to 43%) of reticulum cell sarcomas was ob...

Abstract In this study, we introduce the new concept of $$h$$ h -convex fuzzy-interval-valued functions. Under concept, present versions Hermite–Hadamard inequalities (H–H inequalities) are called fuzzy-interval type for functions ( FIVF) by means fuzzy order relation. This relation is defined level wise thro...