this paper reviews the current literature examining the pervasive symptom of fatigue experienced in three of the most common degenerative neurological conditions: multiple sclerosis (ms), parkinson’s disease (pd) and post-polio syndrome (pps). the existing literature can be considered under four headings definition and prevalence, type, cause, impact of fatigue. fatigue is a common symptom in d...

conclusions our methods will allow us to determine the prevalence of pediatric cfs and me status in the general community. results we provide two case studies showing the types of data we are collecting, and how the data are being used to inform diagnostic decisions. objectives in the present study, we describe an ongoing nih-funded study which will answer basic epidemiologic pediatric issues f...

OBJECTIVE The goal was to characterize prospectively the course and outcome of chronic fatigue syndrome in adolescents during a 2-year period after infectious mononucleosis. METHODS A total of 301 adolescents (12-18 years of age) with infectious mononucleosis were identified and screened for nonrecovery 6 months after infectious mononucleosis by using a telephone screening interview. Nonrecov...

The aims of this study were to determine the characteristics and perceived levels of fatigue and the prevalence of depression in children with chronic fatigue syndrome and to assess the effects of illness on schooling and social functioning. Twelve children with chronic fatigue syndrome were compared with a matched group of children with cystic fibrosis and matched healthy controls. Levels of f...

Phosphate depletion is associated with neuromuscular dysfunction due to changes in mitochondrial respiration that result in a defect of intracellular oxidative metabolism. Phosphate diabetes causes phosphate depletion due to abnormal renal re-absorption of phosphate be the proximal renal tubule. Most of the symptoms presented by patients with phosphate diabetes such as myalgia, fatigue and mild...

About chronic fatigue syndrome Chronic fatigue syndrome is characterised by severe, disabling fatigue, and other symptoms such as musculoskeletal pain, sleep disturbance, impaired concentration and headaches (Reid 2007). The prevalence of chronic fatigue syndrome has been estimated to be from 0.007% to 2.8% in the general adult population, and from 0.006% to 3.0% in primary care, depending on t...

OBJECTIVE To assess the impact of post-polio-related fatigue on quality of life. DESIGN Cross-sectional case control study. SUBJECTS Patients without additional health problems that may induce fatigue were selected from among 82 polio survivors. Twenty-six patients with post-polio syndrome and 10 without post-polio syndrome were included. Control group consisted of 30 healthy volunteers. ...

OBJECTIVE To delineate the risk factors, symptom patterns, and longitudinal course of prolonged illnesses after a variety of acute infections. DESIGN Prospective cohort study following patients from the time of acute infection with Epstein-Barr virus (glandular fever), Coxiella burnetii (Q fever), or Ross River virus (epidemic polyarthritis). SETTING The region surrounding the township of D...

Objectives—Patients with chronic fatigue syndrome complain of physical and mental fatigue that is worsened by exertion. It was predicted that the cognitive and motor responses to vigorous exercise in patients with chronic fatigue syndrome would diVer from those in depressed and healthy controls. Methods—Ten patients with chronic fatigue syndrome, 10 with depressive illness, and 10 healthy contr...

OBJECTIVES Patients with chronic fatigue syndrome complain of physical and mental fatigue that is worsened by exertion. It was predicted that the cognitive and motor responses to vigorous exercise in patients with chronic fatigue syndrome would differ from those in depressed and healthy controls. METHODS Ten patients with chronic fatigue syndrome, 10 with depressive illness, and 10 healthy co...